兰州大学学报（医学版）2026，Vol.52Issue(1)：50-58,9.DOI:10.13885/j.issn.2097-681X.M20250269
血清炎症指数对结缔组织病相关间质性肺病的诊断价值研究
Diagnostic value of inflammatory indices in connective tissue disease-related interstitial lung disease
摘要
Abstract
Objective To explore the correlation between inflammatory indices and connective tissue disease-related interstitial lung disease(CTD-ILD)andtheir diagnostic value.Methods A total of 487 patients with CTD-ILD who were hospitalized for the first time in the Department of Respiratory and Critical Care Medi-cine and the Department of Rheumatology of the First Hospital of Lanzhou University from January 2013 to December 2023 with complete data were retrospectively included,including 68 cases of SSc-ILD,108 cases of PM/DM-ILD,189 cases of RA-ILD,and 122 cases of SS-ILD.At the same time,200 patients with connec-tive tissue disease without interstitial lung disease(CTD-NILD)who visited our hospital during the same peri-od were selected,including 50 cases of SSc-NILD,PM/DM-NILD,RA-NILD and SS-NILD.The clinical data of the patients were collected,and the serum systemic inflammation index(SII),systemic inflammation response index(SIRI),systemic inflammation aggregation index(AISI),and C-reactive protein to albumin ratio(CAR)were calculated.The clinical characteristics of various types of CTD-ILD patients were compared,the independent risk factors for the occurrence of various types of CTD-ILD were screened,and prediction models for various types of CTD-ILD established.Results The average levels of SIRI and CAR in the four groups of CTD-ILD patients were higher than those in the corresponding CTD-NILD patients,and the average levels of SII and AISI in SS-ILD patients were higher than those in SS-NILD patients,with statis-tically significant differences(P<0.05);Logistic multivariate regression analysis showed that age≥56 years,smoking history,Raynaud's phenomenon and SIRI were independent risk factors for the occurrence of ILD in SSc patients;age≥54 years,myalgia,rash,cough and CAR level were independent risk factors for such oc-currence in PM/DM patients;age≥68 years,male gender,smoking history,joint pain,cough and CAR were independent risk factors for such an occurrence in RA patients;age≥65 years,dry mouth,cough,shortness of breath and CAR level were independent risk factors for the occurrence of ILD in SS patients.,The four predic-tion models have good performance.Conclusion This study found that the levels of inflammatory indices SIRI and CAR were higher in patients with CTD-ILD than those in patients with CTD-NILD.Establishing a simple prediction model based on the clinical characteristics and inflammatory index of CTD patients has cer-tain clinical reference value for the early identification of high-risk populations of CTD-ILD.关键词
炎症指数/临床特征/结缔组织病相关间质性肺病/诊断价值/预测模型Key words
inflammatory index/clinical features/connective tissue disease-related interstitial lung disease/di-agnostic value/prediction model分类
医药卫生引用本文复制引用
付郡亭,舒娟,侯媛媛,丁伟娟,包海荣..血清炎症指数对结缔组织病相关间质性肺病的诊断价值研究[J].兰州大学学报（医学版）,2026,52(1):50-58,9.基金项目
国家重点研发计划精准医学研究专项-呼吸系统疾病专病队列研究资助项目(2016YFC0901100) （2016YFC0901100）
甘肃省重点人才资助项目(2025RCXM035) （2025RCXM035）
兰州大学第一医院院内基金资助项目(ldyyyn2023-5) （ldyyyn2023-5）
