兰州大学学报（医学版）2026，Vol.52Issue(1)：71-77,7.DOI:10.13885/j.issn.2097-681X.M20240728
不同表型多囊卵巢综合征患者人体成分和非传统血脂参数特征及相关性分析
Characterization and correlation of body composition and non-traditional lipid in different phenotypes of polycystic ovary syndrome
摘要
Abstract
Objective To investigate the characteristics and correlation of body composition and non-tradition-al lipid parameters in different phenotypes of polycystic ovarian syndrome PCOS).Methods 195 patients with PCOS who attended the Second Hospital of Lanzhou University from July 2022 to May 2024 were included,and PCOS was categorized into four clinical phenotype groups according to the Rotterdam criteria,i.e.pheno-type A-anovulation(OA),hyperandrogenism(HA)and polycystic ovarian morphology(PCOM);phenotype B-HA+OA;phenotype C-HA+PCOM;and phenotype D-OA+PCOM.Results The percentages of phenotypes A,B,C and D in PCOS patients are 36.4%,25.6%,22.1%and 15.9%;the body mass index(BMI),body fat per-centage(BFP),waist-to-hip ratio(WHR),visceral fat area(VFA),basal metabolic rate(BMR)difference,trunk fat percentage(TFP),fasting blood glucose(FBG),fasting insulin(FINS),total cholesterol(TC),triglyc-erides(TG),low-density lipoprotein(LDL),homeostatic model assessment of insulin resistance(HOMA-IR),non-high-density lipoprotein(NON-HDL),TC/HDL,TG/HDL,LDL/HDL and testosterone were significantly higher compared to types B,C and D,and the percentage of protein,minerals,skeletal muscle and high-densi-ty lipoprotein(HDL)were significantly lower;BMI,TFP and testosterone were significantly higher in type B and C PCOS patients compared with type D,and the differences were statistically significant(P<0.05).Con-trolling for relevant confounders,Spearman's bias correlation analysis showed that BMI,BFP,WHR,VFA,TFP,HOMA-IR,NON-HDL,TC/HDL,TG/HDL and LDL/HDL in PCOS patients were positively correlated with testosterone(P<0.05);and BMI,BFP,WHR,VFA and TFP were positively correlated with HOMA-IR,NON-HDL,TC/HDL and LDL/HDL(P<0.05).Conclusion Patients with different phenotypes of PCOS have varying degrees of imbalances in body composition and non-traditional metabolic parameters,with type A being the most severe,type D the least severe,and types B and C in between,and categorization should be made for management of patients with PCOS.关键词
多囊卵巢综合征/表型/人体成分/非传统血脂参数/相关性分析Key words
polycystic ovary syndrome/phenotype/body composition/nontraditional lipid parameters/corre-lation analysis分类
医药卫生引用本文复制引用
马海燕,孙明军,郭钰珍..不同表型多囊卵巢综合征患者人体成分和非传统血脂参数特征及相关性分析[J].兰州大学学报（医学版）,2026,52(1):71-77,7.基金项目
兰州大学第二医院项目(071100136) （071100136）
