南京医科大学学报（自然科学版）2026，Vol.46Issue(3)：366-374,9.DOI:10.7655/NYDXBNSN251013
女性恶性肿瘤患者生育力保存过程中来曲唑辅助卵巢刺激的研究现状与展望
Research status and prospectof the effect of adding letrozole to ovarian stimulation for fertility preservation in female malignant tumor patients
摘要
Abstract
Letrozole is a highly effective non-steroidal aromatase inhibitor that reduces estrogen levels by inhibiting aromatase activity.It has important application value in the field of fertility preservation,especially in patients with malignant tumors.For patients with estrogen-sensitive malignant tumors such as breast cancer,letrozole can reduce the concentration of circulating estrogen in the body during ovulation induction,thereby reducing the adverse effects of high estrogen on tumors during traditional ovulation induction,and effectively promote follicular development.However,the low estrogen level environment in the body brought about by letrozole may lead to decreased oocyte maturity or embryo quality and reduced embryo implantation rate.Further large-scale clinical studies are needed in the future to clarify its long-term safety and efficacy in fertility preservation,and provide more precise treatment strategies for fertility preservation in patients with malignant tumors.关键词
来曲唑/生育力保存/恶性肿瘤/控制性卵巢刺激Key words
letrozole/fertility preservation/malignant tumors/controlled ovarian stimulation分类
医药卫生引用本文复制引用
陶慧敏,徐嗣亮,侯振..女性恶性肿瘤患者生育力保存过程中来曲唑辅助卵巢刺激的研究现状与展望[J].南京医科大学学报（自然科学版）,2026,46(3):366-374,9.基金项目
国家自然科学基金(82001508) （82001508）
江苏省自然科学基金(BK20191491) （BK20191491）
