检验医学与临床2026，Vol.23Issue(5)：577-582,6.DOI:10.3969/j.issn.1672-9455.2026.05.001
单核细胞计数/淋巴细胞计数比值与2型糖尿病周围神经病变的关系
Relationship between monocyte count/lymphocyte count ratio and peripheral neuropathy in type 2 diabetes
摘要
Abstract
Objective To investigate the relationship between monocyte count(MON)/lymphocyte count(LYM)ratio(MLR)and type 2 diabetic mellitus(T2DM)peripheral neuropathy(DPN).Methods A total of 192 patients with T2DM who were hospitalized in the Department of Endocrinology,the First Affiliated Hospital of Army Medical University from December 2024 to June 2025 were enrolled in this study.The pa-tients were divided into DPN group(108 cases)and non-DPN group(84 cases)according to the presence or absence of DPN.Baseline data of all patients were collected.The white blood cell count(WBC),MON,neutro-phil count(NEU),platelet count(PLT),LYM and the levels of glycosylated hemoglobin(HbA1c),fasting plasma glucose(FPG),total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)were detected.The MLR was calculated.According to the MLR,the patients were divided into four groups(Q1 group,Q2 group,Q3 group,Q4 group).Nerve conduc-tion velocity(NCV)and vibration perception threshold(VPT)were measured and recorded.All patients were scored by Toronto Clinical scoring System(TCSS).Spearman correlation was used to analyze the correlation between MLR and related clinical indicators in T2DM patients.Multivariate Logistic regression was used to analyze the influencing factors of DPN in T2DM patients.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of MLR for DPN in T2DM patients.Results The duration of diabetes in DPN group was longer than that in non-DPN group,MLR,FPG level,HbA1c level,VPT,TCSS score and MON were higher than those in non-DPN group,LYM,tibial NCV and fibular NCV in DPN group were lower than those in non-DPN group,and the differences were statistically significant(P<0.05).Spearman correla-tion analysis showed that MLR level was negatively correlated with tibial NCV and fibular NCV(P<0.05),and positively correlated with age,duration of diabetes,TG,FPG,HbA1c,VPT and TCSS score(P<0.05).There were 48 patients in Q1 group,48 in Q2 group,48 in Q3 group and 48 in Q4 group.The prevalence of DPN increased significantly with each quartile increase in MLR,from 22.92%in Q1 group to 77.08%in Q4 group.With the increase of MLR,VPT showed an upward trend,and NCV of tibia and fibula showed a down-ward trend(P<0.001).Multivariate Logistic regression analysis showed that increased MLR and prolonged duration of diabetes were independent risk factors for DPN in T2DM patients(P<0.05).ROC curve analysis showed that the area under the curve of MLR for diagnosing DPN in T2DM patients was 0.734.Conclusion MLR is associated with DPN in T2DM patients,and MLR provides a new direction for the screening of DPN.关键词
2型糖尿病/糖尿病周围神经病变/单核细胞计数/淋巴细胞计数比值/神经传导速度/炎症因子Key words
type 2 diabetes mellitus/diabetic peripheral neuropathy/monocyte count/lymphocyte count ratio/nerve conduction velocity/inflammatory factor分类
医药卫生引用本文复制引用
张欣宇,隆敏,彭桂亮,蒋婷,李紫薇,陈莉,王顺玉,张芃瑞,张玉玲,孙利娟..单核细胞计数/淋巴细胞计数比值与2型糖尿病周围神经病变的关系[J].检验医学与临床,2026,23(5):577-582,6.基金项目
国家四大慢病重大专项(2023ZD0509004) （2023ZD0509004）
陆军军医大学第一附属医院院临床项目(20247TPY07). （20247TPY07）
