检验医学与临床2026，Vol.23Issue(5)：615-620,627,7.DOI:10.3969/j.issn.1672-9455.2026.05.007
外周血ELR、AST/ALT比值与急性冠脉综合征患者冠状动脉病变程度及PCI术后冠状动脉慢血流或无复流的关系
Association of ELR and AST/ALT ratio in peripheral blood with the degree of coronary artery lesion and coronary slow flow or no reflow after PCI in patients with acute coronary syndrome
摘要
Abstract
Objective To investigate the relationship between peripheral blood eosinophil/lymphocyte count ratio(ELR),aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio and the degree of coronary artery lesion(CAL)in patients with acute coronary syndrome(ACS)and coronary slow blood flow(slow flow,CSF),interruption of blood supply,and no blood flow signal(no reflow,CNF)after percuta-neous coronary intervention(PCI).Methods A total of 126 ACS patients admitted to the hospital from May 2022 to May 2024 were selected as the ACS group,and 130 healthy people who underwent physical examina-tion in the hospital during the same period were selected as the control group.ACS patients were divided into mild group,moderate group and severe group according to Gensini score.ACS patients were divided into CSF/CNF group and normal blood flow group according to angiographic evaluation.The clinical data of ACS pa-tients were collected through the electronic medical record system.Spearman correlation analysis was used to analyze the correlation between ELR,AST/ALT ratio and the degree of CAL in ACS patients.Multivariate Logistic regression was used to analyze the influencing factors of CSF or CNF in ACS patients.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of ELR and AST/ALT ratio alone or in combination for CSF or CNF in ACS patients.Results The ACS group had a significantly higher ELR peripheral blood level and a significantly lower AST/ALT ratio than the control group(P<0.05).There were 58 cases in mild group,48 cases in moderate group and 20 cases in severe group.The mild group had a significantly lower ELR and a significantly higher AST/ALT ratio than the moderate and severe groups,and the severe group had a significantly higher ELR and a significantly lower AST/ALT ratio than the moderate group(P<0.05).Spearman correlation analysis showed that peripheral blood ELR was positively correlated with CAL(r=0.465,P<0.001),and AST/ALT ratio was negatively correlated with CAL(r=-0.509,P<0.001).There were 82 cases in the normal blood flow group and 44 cases in the CSF/CNF group.The ELR in CSF/CNF group was higher than that in normal blood flow group,and the AST/ALT ratio and hemoglobin level in CSF/CNF group were lower than those in normal blood flow group,and the differ-ences were statistically significant(P<0.05).Multivariate Logistic regression analysis showed that the in-crease of ELR was a risk factor for CSF or CNF in ACS patients(P<0.05),and the increase of AST/ALT ratio was a protective factor for CSF or CNF in ACS patients(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of ELR,AST/ALT ratio alone and in combination for predicting CSF or CNF in ACS patients was 0.817,0.801 and 0.919 respectively.The AUC of the combined prediction of CSF or CNF in ACS patients was greater than that of ELR or AST/ALT ratio alone(Z=3.379,3.054,P=0.001,0.002).Conclusion ELR is in-creased and AST/ALT ratio is decreased in ACS patients.The changes of ELR and AST/ALT ratio are related to the degree of CAL,and have certain predictive value for CSF or CNF after PCI in ACS patients.关键词
急性冠脉综合征/冠状动脉病变/慢血流/无复流/嗜酸性粒细胞计数/淋巴细胞计数比值/天冬氨酸转氨酶/丙氨酸转氨酶Key words
acute coronary syndrome/coronary artery lesion/slow flow/no reflow/eosinophil count/lymphocyte count ratio/aspartate aminotransferase/alanine aminotransferase分类
医药卫生引用本文复制引用
王皓,王娜,张帆,石小平..外周血ELR、AST/ALT比值与急性冠脉综合征患者冠状动脉病变程度及PCI术后冠状动脉慢血流或无复流的关系[J].检验医学与临床,2026,23(5):615-620,627,7.基金项目
河北省秦皇岛市科学技术研究与发展计划项目(202301A139). （202301A139）
