摘要
Abstract
Objective To investigate the predictive value of peripheral blood T lymphocyte subsets com-bined with β-human chorionic gonadotropin(β-HCG)for pregnancy outcome in patients with threatened abor-tion in early pregnancy.Methods A total of 168 female patients with threatened abortion in early pregnancy admitted to Xianyang Central Hospital from October 2022 to October 2024 were selected as the research ob-jects.According to the pregnancy outcome,the patients were divided into abortion group and non-abortion group.The levels of T lymphocyte subsets(CD3+,CD4+,CD8+)and β-HCG were compared between the a-bortion group and the non-abortion group.The baseline data of the two groups were collected.Multivariate Logistic regression was used to analyze the influencing factors of threatened abortion in early pregnancy.Re-ceiver operating characteristic curve(ROC)was drawn to analyze the predictive value of CD4+,CD8+,β-HCG alone and combined detection in patients with threatened abortion in early pregnancy.Results There were 56 cases in the abortion group and 112 cases in the non-abortion group.The levels of estradiol,CD8+and β-HCG in the abortion group were lower than those in the non-abortion group,and the level of CD4+was higher than that in the non-abortion group,and the differences were statistically significant(P<0.05).The results of multivariate Logistic regression analysis showed that the increase of CD4+level was a risk factor for abortion in patients with threatened abortion in early pregnancy(P<0.05),and the increase of β-HCG and CD8+lev-els were protective factors for abortion in patients with threatened abortion in early pregnancy(P<0.05).ROC curve analysis results showed that the area under the curve(AUC)of CD4+,CD8+and β-HCG alone in predicting miscarriage in patients with threatened abortion in early pregnancy was 0.717,0.713 and 0.708 re-spectively,and the AUC of combined prediction of the three was 0.918,which was greater than AUC predicted by CD4+,CD8+and β-HCG alone(P<0.05).Conclusion CD4+,CD8+and β-HCG are closely related to threatened abortion in early pregnancy,and they are all influencing factors of threatened abortion in early pregnancy.The combination of the three has a high predictive value for abortion in patients with threatened a-bortion in early pregnancy.关键词
孕早期/先兆流产/T淋巴细胞亚群/β-人绒毛膜促性腺激素/预后/预测价值Key words
early pregnancy/threatened abortion/T lymphocyte subsets/β-human chorionic gonado-tropin/prognosis/predictive value分类
医药卫生
