山西中医药大学学报2026，Vol.27Issue(2)：158-164,7.DOI:10.19763/j.cnki.2096-7403.2026.02.12
刘杰民基于"态靶结合"理论辨治胃食管反流病的经验
Professor Liu Jiemin's experience in diagnosing and treating gastroesophageal reflux disease based on the"state-target integration"theory
摘要
Abstract
The"state-target integration"theory,originally proposed by academician Tong Xiaolin,advocates a thera-peutic approach that classifies diseases according to their type,stage,and syndrome differentiation.This theory represents an essential pathway for the development of Traditional Chinese Medicine(TCM)within the context of modern medicine.It comprises two main components:(1)Utilizing modern scientific technologies to uncover the essence of TCM theories—such as Zang-Fu organ theory,meridian theory,as well as syndrome differentiation and treatment—to illustrate the mecha-nisms underlying TCM efficacy and provide explanations grounded in modern science;(2)Employing modern technologies to advance TCM theory itself,refine TCM treatment methods,and enhance clinical outcomes.In this framework,"state"re-fers to a macro-level summary of the core pathogenesis at a specific disease stage,categorized into excess states(e.g.,stag-nation,cold,heat,blood stasis)and deficiency states(e.g.,deficiencies of Qi,blood,Yin,or Yang)."target"denotes micro-level intervention points grounded in modern medical metrics,further classified into disease targets(underlying dis-ease pathology),symptom targets(clinical manifestations),and biomarker targets(physicochemical indicators).The"state-target integration"theory reconstructs the TCM diagnostic and therapeutic system,clarifies the strengths and limita-tions of traditional TCM thinking,enhances clinical reasoning in TCM practice,simplifies the dissemination of TCM meth-odologies,and promotes effective integration and complementarity between TCM and Western medicine—thereby improving treatment precision and clinical operability.Drawing on professor Liu Jiemin's clinical experience,this paper intends to ap-ply the"state-target integration"theory to the diagnosis and treatment of gastroesophageal reflux disease(GERD)to en-hance therapeutic efficacy.Professor Liu posits that GERD initially manifests primarily as a"deficiency state",which pro-gressively evolves into"stagnation","heat"and"blood stasis"states as the disease advances.The principle of"state regu-lation"involves strengthening the spleen and replenishing Qi,soothing the liver and clearing heat,and stop acid regurgita-tion to relieve pain.Building upon state regulation,targeted therapies are implemented by selecting corresponding target-specific formulas and herbs based on diagnostic markers,including esophagogastroduodenoscopy(EGD),24-hour esopha-geal pH monitoring,and predominant clinical symptoms to enhance clinical efficacy,reduce disease recurrence,and offer a novel approach to the clinical management of GERD.关键词
态靶结合/胃食管反流病/刘杰明/胃镜及24 h食管pH监测Key words
state-target integration/gastroesophageal reflux disease/Liu Jiemin/gastroscopy and 24-hour esopha-geal pH monitoring分类
医药卫生引用本文复制引用
陆廷飞,李希希,聂林晖,王柏妹,王佳兰,王敏,刘杰民..刘杰民基于"态靶结合"理论辨治胃食管反流病的经验[J].山西中医药大学学报,2026,27(2):158-164,7.基金项目
国家自然基金项目(82060850、82460924) （82060850、82460924）
贵州省高层次创新型人才项目(黔科合平台人才[2020]6016-2) （黔科合平台人才[2020]6016-2）
贵州省中医药管理局徐学义全国名老中医传承工作室工作站建设项目[黔中医药涵2023(28号)] （28号）
贵州省中医药管理局课题(QZYY-2025-115) （QZYY-2025-115）
