上海中医药杂志2026，Vol.60Issue(3)：11-18,43,9.DOI:10.16305/j.1007-1334.2026.z20250730001
从脾论治轻度认知功能损害的理论探讨与针灸干预策略
Theoretical exploration and acupuncture and moxibustion intervention strategies for mild cognitive impairment from perspective of spleen treatment
摘要
Abstract
Mild cognitive impairment(MCI)is an unstable transitional state between cognitive decline associated with normal brain aging and Alzheimer's disease.In traditional Chinese medicine(TCM),MCI is classified under conditions such as"amnesia",and its occurrence is considered to be associated with spleen deficiency.The spleen is regarded as the source of qi and blood transformation,and its function of ascending clear yang is essential for maintaining vitality,providing a continuous postnatal material basis for the storage of"intent and intellect"attributed to the spleen.With aging,spleen deficiency may result in impaired transformation and transportation,insufficient generation of qi and blood,deficiency of nutritive blood,and weakened ascending of clear yang.Consequently,clear yang fails to ascend,the brain orifices are deprived of nourishment,turbid yin is generated internally and ascends to disturb the clear orifices,ultimately leading to dysfunction of mental activities.This pathophysiological interpretation offers an integrated perspective on the multifactorial mechanisms of MCI identified by modern medicine,including lipid metabolism disorders,increased oxidative stress,neuroinflammatory responses,and gut microbiota dysbiosis.As a non-pharmacological therapy that regulates visceral qi dynamics,acupuncture and moxibustion may act on multiple pathological processes of MCI by strengthening the spleen and promoting the ascending of clear yang,thereby improving cognitive function.From the TCM theoretical perspective of treating MCI through the spleen,acupuncture and moxibustion intervention strategies are proposed to provide new insights and clinical references for the comprehensive management of MCI.关键词
轻度认知功能损害/阿尔茨海默病/脾主升清/针灸/脂质代谢/肠道菌群/氧化应激/作用机制Key words
mild cognitive impairment/Alzheimer's disease/spleen governs ascending lucidity/acupuncture and moxibustion/lipid metabolism/gut microbiota/oxidative stress/mechanism of action引用本文复制引用
邱曼丽,宋哲妤,陈元,赵超蓉,马瑗瑗,陶杰,李璟..从脾论治轻度认知功能损害的理论探讨与针灸干预策略[J].上海中医药杂志,2026,60(3):11-18,43,9.基金项目
国家自然科学基金项目(82274344) （82274344）
上海市科委"科技创新行动计划"医学创新研究专项(23Y11922000) （23Y11922000）
上海市中医药管理局重点领域中医特色病种建设项目(沪卫中管2024-15号) （沪卫中管2024-15号）
上海市卫健委名老中医学术经验研究工作室建设项目(SHGZS-202212) （SHGZS-202212）
上海市普陀区杏林优青培养计划项目(ptxlyq2202) （ptxlyq2202）
