上海中医药杂志2026，Vol.60Issue(3)：33-43,11.DOI:10.16305/j.1007-1334.2025.z20250217003
中药复方治疗儿童感染后咳嗽有效性与安全性的系统评价
Systematic review of efficacy and safety of traditional Chinese medicine compound prescriptions in treating post‑infectious cough in children
摘要
Abstract
Objective To systematically review the clinical efficacy and safety of traditional Chinese medicine(TCM)compound prescriptions in the treatment of post-infectious cough(PIC)in children.Methods A computer-based search was conducted in eight databases,including China National Knowledge Infrastructure(CNKI),WanFang Data,VIP(Chinese Journals Service Platform),SinoMed,PubMed,Embase,Cochrane Library,and Web of Science,for relevant literature on the treatment of PIC in children,with publication dates from the inception of the databases up to December 10,2024.The quality of the included studies was assessed using the Cochrane Handbook for Systematic Reviews of Interventions,and meta-analysis was performed using Review Manager 5.4 software.Results ①A total of 17 studies were included,involving 1,296 children(691 males,and 605 females)aged 1 to 17 years.②The risk of bias in the included studies was assessed using the RoB 2 tool,indicating some studies had potential bias risks.③Meta-analysis results showed that the experimental group had a higher clinical efficacy rate and better TCM syndrome efficacy than the control group[RR=1.18,95%CI(1.13,1.24),P<0.000 01;RR=1.38,95%CI(1.14,1.68),P=0.001].The experimental group also showed better improvement in cough,expectoration,and TCM syndrome scores[SMD=−0.67,95%CI(−0.84,−0.50),P<0.000 01;SMD=−0.52,95%CI(−0.82,−0.21),P=0.000 9;SMD=−1.02,95%CI(−1.21,−0.82),P<0.000 01].The experimental group had a shorter onset and cure time than the control group[SMD=−1.10,95%CI(−1.82,−0.37),P=0.003;SMD=−0.38,95%CI(−0.71,−0.05),P=0.02].The recurrence rate of PIC in children of the experimental group was lower than that in the control group[RR=0.34,95%CI(0.12,0.95),P=0.04].10 articles included in the literature reported adverse reactions,but no adverse events occurred.Conclusions Compared to Western medicine,the use of TCM compound prescriptions alone is more effective in improving cough,expectoration,and TCM syndrome symptoms in children with PIC.It also enhances clinical efficacy,shortens treatment time,and demonstrates high safety.However,the limited number and quality of the included studies require further validation of these findings.关键词
感染后咳嗽/儿童/中药/meta分析/循证医学Key words
post-infectious cough/children/Chinese materia medica/meta-analysis/evidence-based medicine引用本文复制引用
马小敏,刘震,杨雨萌,李骄昌,张天宇,张文涵,吴振起..中药复方治疗儿童感染后咳嗽有效性与安全性的系统评价[J].上海中医药杂志,2026,60(3):33-43,11.基金项目
国家自然科学基金项目(81373687,81874490,82074494) （81373687,81874490,82074494）
辽宁省科技厅应用基础研究计划项目(2022JH2/101300088) （2022JH2/101300088）
