时珍国医国药2026，Vol.37Issue(4)：685-690,6.DOI:10.70976/j.1008-0805.SZGYGY-2026-0411
朝鲜淫羊藿新型自组装纳米粒的构建和评价
Construction and evaluation of novel self-assembled nanoparticles from Epimedium koreanum Nakai via micro-precipitation method
摘要
Abstract
Objective To establish a preparation method for micro-precipitation self-assembled nanoparticles(MP-SAN)derived from Epimedium koreanum and to characterize their physicochemical properties.Methods MP-SAN were prepared from aqueous and ethano-lic extracts of Epimedium koreanum using the microprecipitation method.Particle size,zeta potential,and polydispersity index(PDI)of the nanoparticles were measured.The resulting MP-SAN were further characterized by ultraviolet-visible(UV-Vis)spectroscopy,Fourier-transform infrared(FTIR)spectroscopy,X-ray diffraction(XRD),differential scanning calorimetry(DSC),and thermogravimet-ric analysis(TGA).Encapsulation efficiency and extraction transfer efficiency were evaluated to perform quantitative value transfer analysis of flavonol glycosides in MP-SAN.Results The average particle size of MP-SAN was(265.8±13.5)nm,with a zeta potential of(-10.5±0.6)mV and a PDI of(0.18±0.07).Spectroscopic and thermal analyses indicated that enhanced thermal stability of MP-SAN may be attributed to electron cloud redistribution resulting from molecular recognition among constituents via non-covalent interactions.Quantitative transfer analysis revealed encapsulation efficiencies of 68.74%,60.32%,61.73%,and 58.95%for epimedin A,epimedin B,epimedin C,and icariin,respectively.Corresponding extraction and transfer rates were 72.30%,68.13%,57.87%,and 63.41%.Conclusion The developed MP-SAN preparation method for Epimedium koreanum is simple,rapid,and reproducible.It enhances the extraction and transfer efficiency of poorly soluble components and provides a scientific foundation for the development of novel drug delivery systems for bioactive constituents of Epimedium koreanum.关键词
朝鲜淫羊藿/微沉淀法/自组装纳米粒/新型载药系统Key words
Epimedium koreanum/Micro-precipitation/Self-assembly Nanoparticles/Novel drug delivery systems分类
医药卫生引用本文复制引用
刘思琦,黄云芬,王媛媛,袁子民,王静..朝鲜淫羊藿新型自组装纳米粒的构建和评价[J].时珍国医国药,2026,37(4):685-690,6.基金项目
辽宁省教育厅高校基本科研项目储备项目(2024-JYTCB-054) （2024-JYTCB-054）
辽宁中医药大学大学生创新创业训练项目(X202410162002) （X202410162002）
辽宁省科技计划应用基础研究计划项目(2026021) （2026021）
