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Dual strategies for durable antibodies against SARS-CoV-2:Immune trajectories and viral fitness constraints

Pengyue Gao Linh Nguyen André Costa Lobato George Fu Gao Zhou Tong

微生物与宿主健康（英文）2026，Vol.4Issue(2)：123-126,4.

微生物与宿主健康（英文）2026，Vol.4Issue(2)：123-126,4.DOI:10.1016/j.hlife.2025.10.002

Dual strategies for durable antibodies against SARS-CoV-2:Immune trajectories and viral fitness constraints

Pengyue Gao ¹Linh Nguyen ²André Costa Lobato ³George Fu Gao ²Zhou Tong²

作者信息

1. Division of Life Sciences and Medicine,University of Science and Technology of China,Anhui,China||CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,China
2. CAS Key Laboratory of Pathogen Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing,China
3. Center for Technology Development in Health,Oswaldo Cruz Foundation,Rio de Janeiro,Brazil
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Pengyue Gao,Linh Nguyen,André Costa Lobato,George Fu Gao,Zhou Tong..Dual strategies for durable antibodies against SARS-CoV-2:Immune trajectories and viral fitness constraints[J].微生物与宿主健康（英文）,2026,4(2):123-126,4.

基金项目

We sincerely thank Prof.Xin Zhao for her invaluable assistance with the pseudovirus assays in this study.We also express our deep gratitude to Prof.Xiangxi Wang for kindly providing the BD55-1205 antibody.We are deeply grateful to Jinfeng Wang for her invaluable contribution to the statistical analysis of anti-body evolution data.We appreciate Dr.Wei Zhang for providing technical support with the CQ1 confocal imaging cell counter.This work was funded by the External Cooperation Program of CAS(grant number 180GJHZ2023017MI)to G.F.G. （grant number 180GJHZ2023017MI）

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