日用化学品科学2026，Vol.49Issue(3)：47-52,6.DOI:10.3969/j.issn.1006-7264.2026.03.007
10种花类提取物的活性评价及在化妆品中的应用
Activity evaluation of 10 flower extracts and their application in cosmetics
周雯 1康超 1刘俊杰 2陈鑫宇 2祁晓烨 2程传景3
作者信息
- 1. 天津市药品化妆品审评查验中心,天津 300191
- 2. 天津嘉氏堂科技有限公司,天津 300450
- 3. 天津嘉氏堂科技有限公司,天津 300450||南开大学,天津 300350
- 折叠
摘要
Abstract
To screen floral materials with significant whitening activity and optimize their synergistic ratio for the cosmetic applications,their cosmetic application values have been evaluated.Ten floral extracts were initially screened using DPPH radical scavenging assay and tyrosinase activity inhibition test.The three most active ingredients were selected for the ratio optimization via response surface methodology.The efficacy of the optimized combination was evaluated through B16F10 cell experiments.A lotion containing 0.1％of the optimized combination was formulated for a 28-day human efficacy study(measuring ITA° value and melanin index)and safety assessment.Peony,roselle,and crape myrtle flowers demonstrated that they all have superior antioxidant activity,with the optimal ratio being 1:2:1.9.At this ratio,the 0.1％combination significantly inhibited melanin synthesis(34.67％)and tyrosinase activity(34.99％),while maintained the cell viability(84.30％).Human trials showed a significant increase in ITA° value(+4.45％,p<0.001)and a reduction in melanin content(-14.72％,p<0.001)with good safety profile.The 1:2:1.9 combination of peony flower,roselle flower,and crape myrtle flower exhibits remarkable skin-whitening efficacy,which is suitable for the cosmetic development.关键词
美白功效/玫瑰茄花/牡丹花/紫薇花/响应面设计Key words
whitening effect/roselle flower/peony flower/crape myrtle flower/response surface design分类
化学化工引用本文复制引用
周雯,康超,刘俊杰,陈鑫宇,祁晓烨,程传景..10种花类提取物的活性评价及在化妆品中的应用[J].日用化学品科学,2026,49(3):47-52,6.
