新发传染病电子杂志2026，Vol.11Issue(1)：55-59,5.DOI:10.19871/j.cnki.xfcrbzz.2026.01.009
AIDS合并马尔尼菲篮状菌病患者胸部CT表现与CD4+T淋巴细胞计数的关系
The correlation between chest CT manifestations and CD4+T lymphocyte count in AIDS patients with Talaromycosis
摘要
Abstract
Objective To explore the relationship between the count of CD4+T lymphocyte and the chest CT features including manifestation,distributions of pulmonary lesion,as well as the severity of pulmonary lesion in AIDS patients with Talaromycosis(TSM).Method A retrospective analysis was performed on the clinical data,chest CT findings and CD4+T lymphocyte counts of 122 patients with AIDS complicated by TSM who were admitted to Shanghai Public Health Clinical Center from January 2015 to December 2024.The relationships between CT imaging manifestations/distribution characteristics of pulmonary lesions and CD4+T lymphocyte counts were investigated.The correlations between the number of affected pulmonary segments/CT severity scores and CD4+T lymphocyte counts were analyzed.Result The chest CT manifestations of AIDS patients with TSM were diverse,mainly including miliary nodule,nodule,ground-glass opacity or patchy shadow,and mediastinal lymphadenopathy.There were no significant differences in CD4+T lymphocyte count among groups with different chest CT manifestations(P＞0.05),including between groups with miliary nodule and those without,groups with mediastinal lymphadenopathy and those without,and groups with pulmonary lesion and those without.There were no significant differences in CD4+T lymphocyte count among groups with different distributions of pulmonary lesion(P＞0.05),including between groups with bilateral distribution and non-bilateral distribution,and between groups with diffuse distribution and non-diffuse distribution.The number of lung segment involved by pulmonary lesion and the CT score of pulmonary lesion showed no significant correlation with CD4+T lymphocyte count(P＞0.05).Conclusion This study demonstrates that the pulmonary CT manifestations(including lesion morphology and distribution)and their severity in AIDS patients with Talaromyces marneffei infection show no significant correlation with CD4+T lymphocyte counts.These findings suggest that the imaging characteristics of Talaromyces marneffei infection may be independent of the degree of host immunosuppression,providing a new perspective for understanding the pathogenesis of this disease.关键词
获得性免疫缺陷综合征/马尔尼菲篮状菌/CD4+T淋巴细胞/体层摄影术Key words
Acquired immune deficiency syndrome/Talaromyces marneffei/CD4+T lymphocyte/Tomography分类
医药卫生引用本文复制引用
石秀东,丁晨寒,杨影,宋朋睿,施裕新..AIDS合并马尔尼菲篮状菌病患者胸部CT表现与CD4+T淋巴细胞计数的关系[J].新发传染病电子杂志,2026,11(1):55-59,5.基金项目
1.国家自然科学基金(82302265) （82302265）
2.上海市公共卫生临床中心院内课题(RCJJ-2025-07) （RCJJ-2025-07）
