药食同源杂志2025，Vol.1Issue(10)：40-48,9.
药食同源中药材活性成分干预溃疡性结肠炎作用机制的研究进展
Research progress on the mechanisms of action of active ingredients from food-medicine homologous medicinal materials in intervening ulcerative colitis
摘要
Abstract
Ulcerative colitis(UC)is an intractable chronic inflammatory bowel disease.Conventional Western medical therapies have limitations such as substantial adverse effects,high recurrence rates,and high costs,whereas food-medicine homologous medicinal materials,due to their natural and multi-target characteristics,have gradually become a research hot spot in this field.This article systematically reviews the mechanisms of action of typical food-medicine homologous plants and their active ingredients(including polysaccharides,flavonoids,polyphenols,etc.)in the treatment of UC.Studies have shown that these ingredients can alleviate UC symptoms through anti-inflammatory effects,immunomodulation,intestinal barrier repair,antioxidant activity,and modulation of the gut microbiota.However,there remain certain limitations in the research on food-medicine homologous medicinal materials for UC,such as the current focus on basic experimental research,with insufficient depth of mechanistic studies.In addition,further research is needed on medicinal material quality standardization,elucidation of multi-component synergistic mechanisms,and long-term safety.Future efforts should integrate multi-omics approaches,develop novel delivery systems,and advance the precise and modern application of food-medicine homologous medicinal materials through large-sample clinical trials,thereby providing safer and more effective strategies for UC treatment.关键词
药食同源/中药材/溃疡性结肠炎/作用机制/综述Key words
food-medicine homology/Chinese herbal medicine/colitis/mechanism of action/review分类
医药卫生引用本文复制引用
李蓉,陈朝霞,周立权,周一苗,肖作为..药食同源中药材活性成分干预溃疡性结肠炎作用机制的研究进展[J].药食同源杂志,2025,1(10):40-48,9.基金项目
湖南省自然科学基金项目(2024JJ8163). （2024JJ8163）
