医学新知2026，Vol.36Issue(2)：154-160,7.DOI:10.12173/j.issn.1004-5511.202504153
基于NHANES探讨甘油三酯-葡萄糖指数与骨关节炎的关联
Study on the association between triglyceride-glucose index and osteoarthritis based on NHANES
摘要
Abstract
Objective To analyze the association between the triglyceride-glucose(TyG)index and osteoarthritis(OA).Methods Using data from the National Health and Nutrition Examination Survey of the United States from 2009 to 2020,multivariable Logistic regression and restricted cubic spline(RCS)were used to evaluate the relationship between the TyG index and OA,with threshold-effect analyses performed.Results Among 10,986 participants(1,484 with OA),multivariable Logistic regression showed a significant positive association between the TyG index and OA.After adjustment for age,sex,race,body-mass index,C-reactive protein,and other relevant covariates,each one-unit increase in the TyG index was associated with a 53%higher odds of OA[OR=1.53,95%CI(1.38,1.69)].RCS analysis revealed a non-linear relationship(P<0.001),when TyG index increased and approached 8.5,the risk intensity of OA increased significantly[OR=1.87,95%CI(1.43,2.44)].However,when TyG index≥8.5,the impact of elevated TyG index on OA slowed down[OR=1.18,95%CI(1.03,1.35)].Conclusion The TyG index may serve as a potential biomarker for assessing OA risk.When the TyG index is<8.5,its increase is positively correlated with an elevated risk of OA.Future interventions targeting the TyG index could contribute to lowering OA prevalence.关键词
骨关节炎/甘油三酯-葡萄糖指数/糖尿病/胰岛素抵抗Key words
Osteoarthritis/Triglyceride-glucose index/Diabetes mellitus/Insulin resistance分类
医药卫生引用本文复制引用
谢亮,聂秋,张春榆,林静旖,任青松,柳晶晶,谢玉磊..基于NHANES探讨甘油三酯-葡萄糖指数与骨关节炎的关联[J].医学新知,2026,36(2):154-160,7.基金项目
川北医学院科研合作专项(CBY25-ZXA01) （CBY25-ZXA01）
四川康复医学会科研项目(SCKFKY20250204) （SCKFKY20250204）
