医学新知2026，Vol.36Issue(2)：188-193,6.DOI:10.12173/j.issn.1004-5511.202502065
肠道菌群和血液代谢物与功能性消化不良的因果关系:一项中介孟德尔随机化研究
Causal relationships between gut microbiota and blood metabolites in functional dyspepsia:a mediation Mendelian randomization study
摘要
Abstract
Objective To investigate the causal relationship between gut microbiota and functional dyspepsia(FD)and the potential mediating effects of blood metabolites using Mendelian randomization(MR).Methods Summary-level data were obtained from publicly available genome-wide association studies(GWAS)databases.Genetic instruments were extracted for 473 gut microbial taxa and 233 blood metabolites,and FD GWAS data were sourced from a Finnish database.Two-sample MR was performed to assess the potential associations of gut microbiota and blood metabolites with FD.Sensitivity analyses were conducted to evaluate the robustness of the MR results.Mediation MR was used to explore the potential mediating effects of blood metabolites.Results A total of 29 gut microbial taxa and 2 blood metabolites showed reliable causal relationships with FD(P<0.05).Mediation analysis indicated that the proportion of total cholesterol in high-density lipoprotein(HDL)mediated the causal relationship between Lawsonibacter and FD risk.Conclusion Lawsonibacter was positively correlated with FD,and the proportion of total cholesterol in HDL played a mediating role in this relationship.关键词
肠道菌群/功能性消化不良/血液代谢物/孟德尔随机化/中介效应Key words
Gut microbiota/Functional dyspepsia/Blood metabolites/Mendelian randomization/Mediating effect分类
医药卫生引用本文复制引用
雷佳,王飞勇,何宏伟,张谦,刘静,张越迪,谭壮忱..肠道菌群和血液代谢物与功能性消化不良的因果关系:一项中介孟德尔随机化研究[J].医学新知,2026,36(2):188-193,6.基金项目
内蒙古自治区自然科学基金项目(2023QN08050) （2023QN08050）
内蒙古自治区高等学校科学研究项目(NJZY23135) （NJZY23135）
巴彦淖尔市科技计划项目(K202532) （K202532）
