右江医学2026，Vol.54Issue(2)：139-143,5.DOI:10.3969/j.issn.1003-1383.2026.02.005
右美托咪定对机械通气脓毒症患者肝功能的影响
Effect of dexmedetomidine on hepatic function in septic patients undergoing mechanical ventilation
摘要
Abstract
Objective To investigate the effects of dexmedetomidine-based sedation protocol on liver function and 28-day all-cause in-hospital mortality in septic patients undergoing mechanical ventilation,so as to provide evidence-based support for optimizing sedation strategies in such patients.Methods A total of 88 septic patients undergoing mechanical ventilation admitted to the Emergency Intensive Care Unit(EICU)of Affiliated Hospital of Binzhou Medical College from July 2023 to June 2024 were enrolled.They were divided into observation group(44 cases,treated with dexmedetomidine sedation proto-col)and control group(44 cases,treated with midazolam sedation protocol)using a random number table.The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL),lactic acid(Lac),sequential organ failure assessment(SOFA)scores,acute physiology and chronic health evaluationⅡ(APACHEⅡ)scores,and 28-day all-cause in-hospital mortality were compared between the two groups before treatment and 7 days after treatment.Re-sults 7 days after treatment,the SOFA scores and APACHE Ⅱ scores in both groups were significantly lower than those before treatment(P<0.05),and the improvement in the observation group was better than that in the control group(P<0.05).The levels of ALT,AST,TBIL,and Lac in both groups decreased significantly compared to those before treatment(P<0.05),with the observation group showing a more significant decrease(P<0.05).The 28-day all-cause in-hospital mortality of the observation group within 28 days was 9.09%,significantly lower than that of the control group(29.55%)(χ2=5.906,P=0.015).Conclusion Dexmedetomidine-based sedation protocol can significantly improve liver function indexes and reduce 28-day all-cause in-hospital mortality in septic patients undergoing mechanical ventilation,and has poten-tial for multi-organ function protection.However,its specific mechanism of action and long-term efficacy still need to be fur-ther verified by large-sample prospective studies.关键词
脓毒症/机械通气/右美托咪定/肝功能保护/病死率Key words
sepsis/mechanical ventilation/dexmedetomidine/liver function protection/mortality分类
医药卫生引用本文复制引用
郭立莎,徐树莹..右美托咪定对机械通气脓毒症患者肝功能的影响[J].右江医学,2026,54(2):139-143,5.基金项目
滨州医学院科技计划项目(BY2021KJ05) （BY2021KJ05）
