中国病毒学2025，Vol.40Issue(2)：225-235,11.DOI:10.1016/j.virs.2025.03.010
The SARS-CoV-2 NSP4 T492I mutation promotes double-membrane vesicle formation to facilitate transmission
The SARS-CoV-2 NSP4 T492I mutation promotes double-membrane vesicle formation to facilitate transmission
摘要
关键词
SARS-CoV-2/Virus transmission/NSP4 T492I mutation/DMV/Homodimerization/ER membrane curvatureKey words
SARS-CoV-2/Virus transmission/NSP4 T492I mutation/DMV/Homodimerization/ER membrane curvature引用本文复制引用
Pei Wang,Buyun Tian,Ke Xiao,Wei Ji,Zonghong Li..The SARS-CoV-2 NSP4 T492I mutation promotes double-membrane vesicle formation to facilitate transmission[J].中国病毒学,2025,40(2):225-235,11.基金项目
The TEM studies were performed at the Center for Biological Imaging(CBI),Institute of Biophysics,Chinese Academy of Sciences.We thank Xixia Li,Zhongshuang Lv,Xueke Tan and Can Peng at CBI for their assistance in EM sample preparations.We thank Qing Zhang from Pro-teomics and Metabolomics Core Facility,Guangzhou National Labora-tory,for her assistance with the MS sample preparation and analysis.This work was supported by the National Natural Science Foundation of China(92469107 to Z.Li),the R&D Program of Guangzhou National Labora-tory(ZL-SRPG2200205 to Z.Li),and the Guangdong Province High-level Talent Youth Project(2021QN02Y939 to Z.Li). （CBI）
