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Structure-function insights into the dual role of African swine fever virus pB318L:A typical geranylgeranyl-diphosphate synthase and a nuclear import protein

Hai-Fan Zhao Heng Zhang Ying Wang Xiao-Hong Liu Xian-Hui Liu Zhi Geng Zeng-Qiang Gao Li Huang Chang-Jiang Weng Yu-Hui Dong

中国病毒学2025，Vol.40Issue(2)：236-246,11.
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中国病毒学2025，Vol.40Issue(2)：236-246,11.DOI:10.1016/j.virs.2025.03.013

Structure-function insights into the dual role of African swine fever virus pB318L:A typical geranylgeranyl-diphosphate synthase and a nuclear import protein

Structure-function insights into the dual role of African swine fever virus pB318L:A typical geranylgeranyl-diphosphate synthase and a nuclear import protein

Hai-Fan Zhao 1Heng Zhang 2Ying Wang 3Xiao-Hong Liu 4Xian-Hui Liu 5Zhi Geng 2Zeng-Qiang Gao 2Li Huang 4Chang-Jiang Weng 4Yu-Hui Dong2

作者信息

  • 1. School of Life Sciences,University of Science and Technology of China,Hefei 230027,China||Beijing Synchrotron Radiation Facility,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China
  • 2. Beijing Synchrotron Radiation Facility,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China
  • 3. Beijing Synchrotron Radiation Facility,Institute of High Energy Physics,Chinese Academy of Sciences,Beijing 100049,China||Key Laboratory of Integrated Pest Management on Crops in East China,Ministry of Agriculture,Nanjing Agricultural University,Nanjing 210095,China
  • 4. State Key Laboratory for Animal Disease Control and Prevention,Harbin Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Harbin 150040,China
  • 5. College of Animal Science and National Engineering Center for Swine Breeding Industry,South China Agricultural University,Guangzhou 510642,China
  • 折叠

摘要

关键词

African swine fever virus(ASFV)/Prenyltransferase/Geranylgeranyl-diphosphate synthase/Crystal structure/Nuclear localization signal/Immune evasion

Key words

African swine fever virus(ASFV)/Prenyltransferase/Geranylgeranyl-diphosphate synthase/Crystal structure/Nuclear localization signal/Immune evasion

引用本文复制引用

Hai-Fan Zhao,Heng Zhang,Ying Wang,Xiao-Hong Liu,Xian-Hui Liu,Zhi Geng,Zeng-Qiang Gao,Li Huang,Chang-Jiang Weng,Yu-Hui Dong..Structure-function insights into the dual role of African swine fever virus pB318L:A typical geranylgeranyl-diphosphate synthase and a nuclear import protein[J].中国病毒学,2025,40(2):236-246,11.

基金项目

We thank Dr.Fengxia Zhang(Institute of Genetics and Developmental Biology,Chinese Academy of Sciences)for providing technical support on GGPP determination by LC-QQQ-MS/MS.This study was financially supported by the grants from the National Natural Science Foundation of China to Heng Zhang(31970152),the Strategic Priority Research Pro-gram of CAS to Yu-Hui Dong(XDB37040302)and the CAS Emergency Research Project on African Swine Fever to Yu-Hui Dong(Grant KJZD-SW-L06-01). （Institute of Genetics and Developmental Biology,Chinese Academy of Sciences）

中国病毒学

OACSCD

1003-5125

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