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The SARS-CoV-2 3CL protease inhibits pyroptosis through the cleavage of gasdermin D

Yecheng Zhang Xinlei Ji Dan Huang Gen Lu Xinwen Chen

中国病毒学2025，Vol.40Issue(3)：324-332,9.

中国病毒学2025，Vol.40Issue(3)：324-332,9.DOI:10.1016/j.virs.2025.03.006

The SARS-CoV-2 3CL protease inhibits pyroptosis through the cleavage of gasdermin D

Yecheng Zhang ¹Xinlei Ji ²Dan Huang ²Gen Lu ¹Xinwen Chen²

作者信息

1. Department of Respiratory,Guangzhou Women and Children's Medical Center,Guangzhou Medical University,Guangzhou,Guangdong 510623,China
2. Guangzhou National Laboratory,Guangzhou 510005,China
折叠

摘要

关键词

SARS-CoV-2/3C-like(3CL)protease/Gasdermin D(GSDMD)/Pyroptosis

Key words

SARS-CoV-2/3C-like(3CL)protease/Gasdermin D(GSDMD)/Pyroptosis

引用本文复制引用

Yecheng Zhang,Xinlei Ji,Dan Huang,Gen Lu,Xinwen Chen..The SARS-CoV-2 3CL protease inhibits pyroptosis through the cleavage of gasdermin D[J].中国病毒学,2025,40(3):324-332,9.

基金项目

This work was supported by the National Natural Science Foundation of China(82370015).Experiments related to SARS-CoV-2 were carried out at the National Biosafety Laboratory.We are particularly grateful to Tao Du,Jin Xiong and Min Hou from the National Biosafety Laboratory and the team running the laboratory for their work.We extend our special thanks to Prof.Rongjuan Pei and Hao Sun,Yi Zheng,Yongli Zhang from Chinese Academy of Sciences for their significant assistance in this study.We also thank the other members of the Xinwen Chen and Gen Lu's lab for their constructive comments. （82370015）

中国病毒学

OACSCD

ISSN：1003-5125

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