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Host factor RBM25 promotes HBV replication through Yin Yang 1-mediated cccDNA transcription

Yukun Li Guochao Wei Lin Wang Yongzhen Liu Xiaojing Zhang Shourong Liu Xiangmei Chen Fengmin Lu Tianhao Mao Liwei Zheng Zhao Zhou Qianqian Jiang Xinyu Du Ziyuan Ma Xin Liu Ting Zhang

中国病毒学2025，Vol.40Issue(3)：374-387,14.
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中国病毒学2025，Vol.40Issue(3)：374-387,14.DOI:10.1016/j.virs.2025.05.004

Host factor RBM25 promotes HBV replication through Yin Yang 1-mediated cccDNA transcription

Host factor RBM25 promotes HBV replication through Yin Yang 1-mediated cccDNA transcription

Yukun Li 1Guochao Wei 1Lin Wang 1Yongzhen Liu 2Xiaojing Zhang 3Shourong Liu 3Xiangmei Chen 1Fengmin Lu 1Tianhao Mao 1Liwei Zheng 1Zhao Zhou 1Qianqian Jiang 4Xinyu Du 5Ziyuan Ma 6Xin Liu 1Ting Zhang1

作者信息

  • 1. Department of Microbiology&Infectious Disease Center,School of Basic Medical Sciences,Peking University,Beijing,100191,China
  • 2. Model Animal Research Center,Medical School of Nanjing University,Nanjing,210061,China
  • 3. Department of Hepatology,Hangzhou Xixi Hospital,Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University,Hangzhou,310023,China
  • 4. Peking University People's Hospital,Peking University Hepatology Institute,Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Disease,Beijing International Cooperation Base for Science and Technology on NAFLD Diagnosis,Beijing,100044,China
  • 5. Precision Medicine Center,Academy of Medical Sciences,Zhengzhou University,Zhengzhou,450052,China
  • 6. School of Medical Sciences,University of Sydney,Sydney,NSW,2050,Australia
  • 折叠

摘要

关键词

Hepatitis B virus(HBV)/Covalently closed circular DNA(cccDNA)/cccDNA transcription/RNA binding motif protein 25(RBM25)/Yin Yang 1(YY1)/Acetylated histones

Key words

Hepatitis B virus(HBV)/Covalently closed circular DNA(cccDNA)/cccDNA transcription/RNA binding motif protein 25(RBM25)/Yin Yang 1(YY1)/Acetylated histones

引用本文复制引用

Yukun Li,Guochao Wei,Lin Wang,Yongzhen Liu,Xiaojing Zhang,Shourong Liu,Xiangmei Chen,Fengmin Lu,Tianhao Mao,Liwei Zheng,Zhao Zhou,Qianqian Jiang,Xinyu Du,Ziyuan Ma,Xin Liu,Ting Zhang..Host factor RBM25 promotes HBV replication through Yin Yang 1-mediated cccDNA transcription[J].中国病毒学,2025,40(3):374-387,14.

基金项目

This study was supported by the National Key R&D Program of China(No.2022YFA1303600 and No.2023YFC2306800),the National Natural Science Foundation of China(No.82372235 and No.82272315),and the Sanming Project of Medicine in Shenzhen(No.SZSM202311032).In addition,we thank Professor Qiang Deng for providing the prcccDNA and pCMV-Cre plasmids. （No.2022YFA1303600 and No.2023YFC2306800）

中国病毒学

OACSCD

1003-5125

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