局解手术学杂志2026，Vol.35Issue(3)：265-269,5.DOI:10.11659/jjssx.04E025096
cGAS-STING通路在骨与关节疾病中的研究进展
Research progress of the cGAS-STING pathway in bone and joint diseases
摘要
Abstract
The cyclic guanosine-adenosine synthetase-interferon gene stimulating factor(cGAS-STING)pathway is the core signaling axis by which cytosolic DNA triggers innate immunity and inflammatory responses,and its dysregulation is closely associated with the development of various bone and joint diseases.Activation of this pathway in osteosarcoma can enhance anti-tumor immunity,whereas its persistent activation in multiple degenerative and inflammatory joint diseases can promote sterile inflammation and tissue degeneration,making it an important therapeutic target.This article reviews the latest research progress of the cGAS-STING pathway in bone and joint diseases,aiming to provide a reference for its clinical treatment.关键词
cGAS-STING通路/骨和关节/骨肉瘤/骨质疏松症/椎间盘退变/骨关节炎Key words
cGAS-STING pathway/bones and joint/osteosarcoma/osteoporosis/intervertebral disc degeneration/osteoarthritis分类
医药卫生引用本文复制引用
胡清,史冲,阮默,王颖娜,蒙旭晗..cGAS-STING通路在骨与关节疾病中的研究进展[J].局解手术学杂志,2026,35(3):265-269,5.基金项目
国家自然科学基金面上项目(31970515) （31970515）
云南省骨科与运动康复临床医学研究中心项目(202102AA310068) （202102AA310068）
