中国癌症杂志2026，Vol.36Issue(2)：154-161,8.DOI:10.19401/j.cnki.1007-3639.2026.02.007
夜班工作与女性恶性肿瘤发生风险的初步分析:一项前瞻性队列研究
Preliminary analysis of night shift work and the risk of cancer in Chinese women:a prospective cohort study
摘要
Abstract
Background and purpose:Night shift work has been suggested to potentially increase the risk of cancer.However,prospective population-based evidence remains limited,particularly among Chinese populations.This study aimed to examine the associations between multiple dimensions of night shift work-including ever exposed to night shift work,age of starting night shift work,cumulative night shift work duration,and average monthly frequency of night shifts-and the risk of cancer incidence among Chinese women.Methods:A prospective study was conducted based on the Shanghai Women's Health Study.Night shift exposure was assessed via questionnaire,and incident cancer cases were identified through a combination of active and passive follow-up.The cohort was recruited from December 1996 to May 2000 in Changning District,Shanghai,comprising women aged 40-70 who met the inclusion and exclusion criteria.Associations between night shift exposure variables and cancer risk were evaluated using Cox proportional hazards regression models.Continuous night shift exposure variables were further incorporated into models as continuous form to test for linear trends,and restricted cubic splines were employed to explore the potential non-linear associations.This study was approved by the Renji Hospital Ethics Committee of Shanghai Jiao Tong University School of Medicine(KY2024-050-C)and acquired imformed consent.Results:This study included 69 244 women.With a mean follow-up of 15.8 years,8 442 cancer cases were documented.The multivariate adjusted hazard ratios of night shift exposure variables-ever exposed to night shift work,age of starting night shift work,cumulative night shift work duration,and average monthly frequency of night shifts-in relation to cancer risk were not statistically significant.Furthermore,no significant linear or non-linear associations were detected for any of these continuous night shift variables in relation to cancer incidence(P>0.05).Conclusion:This study did not identify significant associations between night shift work,in any of the dimensions examined,and cancer risk in Chinese women.Further large-scale and rigorously designed prospective studies are warranted to provide reliable population-based evidence.关键词
夜班/癌症/队列研究/前瞻性研究/女性Key words
Night shift/Cancer/Cohort study/Prospective study/Women分类
医药卫生引用本文复制引用
沈秋明,谭玉婷,李卓颖,方婕,李泓澜,项永兵..夜班工作与女性恶性肿瘤发生风险的初步分析:一项前瞻性队列研究[J].中国癌症杂志,2026,36(2):154-161,8.基金项目
上海市抗癌协会"雏鹰"计划(SACA-CY23C03). Shanghai Anticancer Association EYAS PROJECT(SACA-CY23C03). （SACA-CY23C03）
