中国癌症杂志2026，Vol.36Issue(2)：174-179,6.DOI:10.19401/j.cnki.1007-3639.2026.02.009
黑色素瘤不同器官转移机制的研究进展及展望
Progress and perspectives in the research on mechanisms of organ-specific metastasis in melanoma
摘要
Abstract
Melanoma is a highly aggressive skin tumor and the leading cause of skin cancer related death.It can spread from a relatively small primary tumor and metastasize to multiple sites,including lymph nodes,liver,lung,brain,and bone,among others.Metastatic melanoma occurs when tumor cells separate from the primary lesion,migrate with circulating blood flow,penetrate the extracellular matrix and invade blood vessels and/or lymphatics,and form tumors at a distance.The ability of melanoma to metastasize is one of the key factors in the treatment and prognosis of this disease.In recent years,important progress has been made in the study of the mechanism of malignant melanoma metastasis.For instance,activation of signaling pathways promotes the formation of vasculogenic mimicry,thereby inducing the growth of metastatic foci,while genetic mutations drive metabolic adaptation and reprogramming of the tumor microenvironment.This review aims to summarize the relevant literature in recent years and explore the key mechanisms of malignant melanoma metastasis to different organs,including gene mutation,epithelial-mesenchymal transition,tumor microenvironment,and signal transduction pathways.By gaining insight into these mechanisms,we can better understand the metastatic process of malignant melanoma and provide a theoretical basis for the development of new therapeutic strategies.关键词
恶性黑色素瘤/转移机制/肿瘤微环境/信号转导通路/基因突变Key words
Malignant melanoma/Metastasis mechanism/Tumor microenvironment/Signal transduction pathway/Gene mutation分类
医药卫生引用本文复制引用
费一鸣,赵莲君,任宇,邹征云..黑色素瘤不同器官转移机制的研究进展及展望[J].中国癌症杂志,2026,36(2):174-179,6.基金项目
国家自然科学基金(82073365、81872484) （82073365、81872484）
南京大学医学院附属南京鼓楼医院临床研究专项资金(2024-LCYJ-DBZ-01). National Natural Science Foundation of China(82073365,81872484) （2024-LCYJ-DBZ-01）
Funding for Clinical Trials from Nanjing Drum Tower Hospital,Affiliated Hospital of Medical School,Nanjing University(2024-LCYJ-DBZ-01). （2024-LCYJ-DBZ-01）
