中国免疫学杂志2026，Vol.42Issue(3)：513-519,7.DOI:10.3969/j.issn.1000-484X.2026.03.001
TCR与肽-MHC结合中的化学作用力与机械力及其在病毒感染中的作用
Chemical and mechanical forces in TCR-peptide-MHC binding and their roles in viral infection
摘要
Abstract
Interaction between T cell receptor(TCR)and antigen peptide-major histocompatibility complex(pMHC)is a central component of adaptive cellular immune response.TCR-pMHC binding is governed not only by chemical forces,such as affinity,avidity and functional avidity(FA),but is also dynamically regulated by mechanical forces,which in turn influence binding conforma-tion and subsequent signal transduction.Therefore,process of T cell antigen recognition and activation are intricately linked to both chemical and mechanical forces.In context of viral infections,interplay of forces between TCR and pMHC exhibits distinct characteris-tics and plays differential roles in T cell responses,viral clearance and immune escape,depending on specific pathogen and infection state.This review focuses on elucidating mechanisms by which chemical and mechanical forces act in TCR-pMHC binding process and regulate T cell responses during viral infections.It further explores how mechanical forces can complement traditional chemical forces.By integrating insights from both chemical and mechanical perspectives,this review aims to provide novel ideas and strategies for immunotherapy of viral infectious diseases.关键词
T细胞受体/抗原肽-MHC复合物/化学作用力/机械力/病毒感染Key words
T cell receptor/Peptide-MHC complex/Chemical force/Mechanical force/Viral infection分类
医药卫生引用本文复制引用
赵珂璇,许晓悦,左佳佳,张宇丝,张春梅,张赟,陈丽华,马樱..TCR与肽-MHC结合中的化学作用力与机械力及其在病毒感染中的作用[J].中国免疫学杂志,2026,42(3):513-519,7.基金项目
国家自然科学基金项目(82341071,82272331) （82341071,82272331）
陕西省自然科学基础研究重点项目(2023-JC-ZD-49,2022JZ-45) （2023-JC-ZD-49,2022JZ-45）
陕西省自然科学基础研究面上项目(2023-JC-YB-640) （2023-JC-YB-640）
陕西省重点研发计划(2024SF-YBXM-286). （2024SF-YBXM-286）
