中国免疫学杂志2026，Vol.42Issue(3)：520-527,8.DOI:10.3969/j.issn.1000-484X.2026.03.002
HIV潜伏感染细胞模型的研究进展及应用
Research progress and application of HIV latent infection cell model
摘要
Abstract
Even with antiretroviral therapy,acquired immunodeficiency syndrome(AIDS)cannot be completely cured,because HIV-1 can repeatedly establish an infection in the body and form stable latent reservoirs.HIV latent reservoir possesses characteristics such as concealment and a long half-life.Forming after HIV infects the human body,it persists within the host long-term,representing a major challenge and hot topic in current AIDS research.Among them,the establishment and application of HIV-1 latent infection cell models serve as valuable tools for studying HIV latent reservoirs.This paper aims to review and summarise recent advances in the research of latent infection models in CD4+T cells,macrophages,dendritic cells,haematopoietic progenitor cells and astrocytes,and their applications.It provides effective tools for investigating mechanisms of HIV latent reservoir clearance and for developing drugs to achieve a functional cure for AIDS.关键词
潜伏储存库/细胞模型/潜伏机制/药物研发Key words
Latent repository/Cell model/Latent mechanism/Drug research and development分类
医药卫生引用本文复制引用
马润红,李强,桑锋,杨瑶瑶,李杰,刘真,邓博文,徐梦丽,袁硕阳,张清燕..HIV潜伏感染细胞模型的研究进展及应用[J].中国免疫学杂志,2026,42(3):520-527,8.基金项目
国家自然科学基金(82104559,82274474) （82104559,82274474）
河南省科技攻关项目(232102310462,242102310314,242102310519) （232102310462,242102310314,242102310519）
河南省卫生健康委国家中医临床研究基地科研专项(2022JDZX019) （2022JDZX019）
河南省科技研发计划联合基金(232301420080) （232301420080）
河南省中医药科学研究专项课题(2024ZY2019) （2024ZY2019）
河南省医学科技攻关计划项目(LH-GJ20230678) （LH-GJ20230678）
河南中医药大学研究生科研创新类项目(2023KYCX060). （2023KYCX060）
