中国免疫学杂志2026，Vol.42Issue(3)：528-533,6.DOI:10.3969/j.issn.1000-484X.2026.03.003
Wnt/β-catenin信号通路与HIV感染:免疫调节的潜在联系
Wnt/β-catenin signaling pathway and HIV infection:Potential links in immune regulation
摘要
Abstract
Wnt signaling pathway consists of Wnt ligands,receptors,and their downstream signaling molecules,with signal transduction modes divided into classical and non-classical pathways.It plays a role in various processes within the immune system,including the regulation of immune cell development,survival and immune responses.Research has found that abnormal regulation of classical Wnt/β-catenin signaling pathway is closely associated with human immunodeficiency virus(HIV)infection.After β-catenin entering the cell,through its nuclear transcription factor T cell factor(TCF),plays a crucial role in regulating the number and func-tion of immune cells in HIV-infected individuals,HIV viral latency and reactivation,HIV viral replication,and the occurrence of fer-roptosis in cells.This article summarizes the interrelated mechanisms among Wnt/β-catenin signaling pathway,ferroptosis and HIV within the context of HIV infection.关键词
人类免疫缺陷病毒(HIV)/Wnt/β-catenin信号通路/T细胞因子(TCF)/铁死亡Key words
Human immunodeficiency virus(HIV)/Wnt/β-catenin signaling pathway/T cell factor(TCF)/Ferroptosis分类
医药卫生引用本文复制引用
陶泽宇,高精洧,谢丽..Wnt/β-catenin信号通路与HIV感染:免疫调节的潜在联系[J].中国免疫学杂志,2026,42(3):528-533,6.基金项目
国家自然科学基金(82360412) （82360412）
广西自然科学基金(2024GXNSFAA010119). （2024GXNSFAA010119）
