中国免疫学杂志2026，Vol.42Issue(3)：534-540,7.DOI:10.3969/j.issn.1000-484X.2026.03.004
肠道病毒71感染的免疫逃逸机制研究进展
Research progress on immune escape mechanisms of enterovirus 71 infection
摘要
Abstract
Enterovirus 71(EV71)is a positive-sense single-stranded RNA virus responsible for severe diseases such as hand,foot,and mouth disease and neurological damage in young children.The process of EV71 infection involves intricate interac-tions between the virus and the host immune system.Crucially,EV71 evades immune attack by interfering with multiple host immune signaling pathways,thereby promoting its survival and replication.This article begins with a brief description of the EV71 infection process,initiated by binding to host cell surface receptors.It highlights the pivotal roles played by both its structural and non-structur-al proteins in viral entry and subsequent immune evasion.The review focuses in detail on the mechanisms employed by EV71 to evade host immunity.These mechanisms include:Inhibition of innate immune signaling pathways,evasion of adaptive immune responses,modulation of host cell apoptosis and autophagy and interference with the complement system.A deeper understanding of EV71's infec-tion mechanisms and immune evasion strategies is essential for elucidating the molecular basis of its pathogenesis.Furthermore,this knowledge provides a critical theoretical foundation for developing more effective antiviral therapeutics and vaccines.关键词
EV71/结构蛋白/抗体/免疫逃逸/综述Key words
EV71/Structural proteins/Antibodies/Immune evasion/Review分类
医药卫生引用本文复制引用
郭堃,田文霞,陈静,李玉霞..肠道病毒71感染的免疫逃逸机制研究进展[J].中国免疫学杂志,2026,42(3):534-540,7.基金项目
国家自然科学基金(82160921). （82160921）
