中国免疫学杂志2026，Vol.42Issue(3)：547-554,8.DOI:10.3969/j.issn.1000-484X.2026.03.006
白三烯B4水平与系统性红斑狼疮患者T淋巴细胞亚群的关系及对感染风险的预测
Relationship between leukotriene B4 level and T lymphocyte subsets in systemic lupus erythematosus patients and their prediction of infection risk
摘要
Abstract
Objective:To explore the relationship between leukotriene B4(LTB4)level and T lymphocyte subsets in systemic lupus erythematosus(SLE)patients,and predicting the risk of infection.Methods:SLE patients(n=156)who visited Cangzhou Central Hospital from May 2021 to October 2024 were selected as research subjects.According to whether there were co-infections,they were divided into infected group(n=65)and non infected group(n=91).Multiple Logistic regression was used to analyze risk factors and calculate the odds ratio(OR)of risk factors.Linear regression was used to analyze the correlation.Restricted cubic splines(RCS)was used to analyze dose-response relationships.Receiver operating characteristic(ROC)curve was used to analyze the predictive value.Unconditional Logistic regression model and calculation table were used to analyze the interaction effects.Results:Common infection sites of SLE combined infections were the respiratory tract(71.79%),gastrointestinal tract(18.59%)and urinary tract(12.82%),and the common pathogens of infection were bacteria(59.62%),fungi(12.18%)and viruses(10.26%).Multiple factor analysis showed that SLEDAI score,Hb,ALB,CRP,LTB4,CD4+T cells and CD8+T cells were independent influencing factors for SLE co infec-tion(P<0.05).Subgroup analysis showed that there was a stable correlation between LTB4 levels and SLE co infection under different confounding factors,and there was no interaction between subgroups(Ptrend<0.05,Pinteraction>0.05).Linear regression analysis showed that LTB4 was negatively correlated with total T cells,CD4+T cells,CD8+T cells(β<0,P<0.05),and positively correlated with CD4+T/CD8+T(β>0,P<0.05);after adjusting for a series of confounding factors,there was still a significant correlation(P<0.05).RCS analysis showed a non-linear relationship between LTB4 level and the risk of SLE co-infection(nonlinear test P<0.001).ROC curve analysis showed that LTB4 predicted an area under curve(AUC)of 0.892(95%CI:0.842～0.942)for SLE co-infection.Interaction analysis showed that there was an additive interaction between LTB4 level(≥315.80 pg/mL)and CD4+T cells(<396.88 cells/µL),CD8+T cells(<364.50 cells/µL)in SLE co-infection(P<0.05).Conclusion:There is a significant correlation between LTB4 level and T lymphocyte subsets in SLE patients,and it is an independent influencing factor for SLE co-infection.Level of LTB4 has an additive in-teraction with CD4+T cells and CD8+T cells on the risk of SLE co-infection.关键词
系统性红斑狼疮/白三烯B4/T淋巴细胞亚群/感染Key words
Systemic lupus erythematosus/Leukotriene B4/T lymphocyte subsets/Infection分类
医药卫生引用本文复制引用
李艳霞,庞杰,张宗芳,李静,左艳华..白三烯B4水平与系统性红斑狼疮患者T淋巴细胞亚群的关系及对感染风险的预测[J].中国免疫学杂志,2026,42(3):547-554,8.基金项目
河北省医学科学研究课题计划项目(20251550). （20251550）
