中国免疫学杂志2026，Vol.42Issue(3)：567-573,580,8.DOI:10.3969/j.issn.1000-484X.2026.03.009
布拉氏酵母菌对幽门螺杆菌感染患者肠道菌群和炎症因子水平的影响
Effect of Saccharomyces boulardii on gut microbiota and inflammatory factors levels in patients infected with Helicobacter pylori
摘要
Abstract
Objective:To investigate the effect of Saccharomyces boulardii powder on intestinal flora and inflammatory factors in patients with Helicobacter pylori(Hp)infection.Methods:A total of 280 Hp-positive patients admitted to the Second Affiliated Hospital of Xingtai Medical College from November 2024 to June 2025 were enrolled as the research subjects.Using the random number table method,the patients were divided into four groups(A,B,C,and D)at a 1∶1∶1∶1 ratio,with 70 patients in each group.Group A received quadruple therapy alone;Group B received quadruple therapy plus Saccharomyces boulardii powder for 1 week;Group C received the same dosage of Saccharomyces boulardii powder as Group B but extended the course to 2 weeks;Group D received half the dosage of Saccharomyces boulardii powder for 2 weeks.F-test or χ² test were used to analyze the baseline data,intestinal flora,inflam-matory factors,Hp eradication rate,and adverse reactions among the four groups of patients.Levels of intestinal flora,inflammatory factors,and intestinal barrier function indicators in the four groups were compared before treatment,as well as at 1 week,2 weeks,and 3 weeks after treatment.Results:Comparison results of the baseline data among the four groups of patients indicated that there were statistically significant differences(P<0.05)in albumin(ALB),gender,alanine aminotransferase(ALT),aspartate aminotrans-ferase(AST),body mass index(BMI),and alkaline phosphatase(ALP)across the four groups;results of comparing the intestinal flora,inflammatory factors,and intestinal barrier function indices of the four groups showed that,in all four groups,levels of Bifido-bacterium and Lactobacillus at 3 weeks after treatment were sequentially higher than those at 2 weeks after treatment,1 week after treatment,and before treatment,while levels of Enterobacter,Enterococcus,TNF-α,IL-6,C-reactive protein(CRP),diamine oxidase(DAO),D-lactic acid(D-LA)and serum Zonulin at 3 weeks after treatment were sequentially lower than those at 2 weeks after treat-ment,1 week after treatment,and before treatment,and that at 1 week,2 weeks,and 3 weeks after treatment,levels of Bifidobacterium and Lactobacillus in Group C were all higher than those in Group A,B and D,while levels of Enterobacter and Enterococcus in Group C were all lower than those in Group A,B and D.Results of comparing Hp eradication rates and adverse reactions among the four groups revealed that the Hp eradication rate in Group C was higher than that in Group A,B and D,with a statistically significant differ-ence(P<0.05),and the incidence of adverse reactions in Group C was lower than that in Groups A,B and D,though the difference was not statistically significant(P>0.05).Conclusion:Saccharomyces boulardii has a good therapeutic effect on improving the intestinal flora and inflammatory factor levels in patients with Hp infection,and can effectively improve the Hp eradication rate.Among them,the treatment regimen of 0.5 g twice a day for 2 weeks has a more significant therapeutic effect.关键词
布拉氏酵母菌散/幽门螺杆菌/肠道菌群/炎症因子Key words
Saccharomyces boulardii powder/Helicobacter pylori/Gut microbiota/Inflammatory factors分类
医药卫生引用本文复制引用
刘玉龄,窦龙涛,李会龙,张新飞,刘石柱,贾书晓..布拉氏酵母菌对幽门螺杆菌感染患者肠道菌群和炎症因子水平的影响[J].中国免疫学杂志,2026,42(3):567-573,580,8.基金项目
邢台市重点研发计划项目社会发展领域专项(2024ZC263). （2024ZC263）
