中国比较医学杂志2026，Vol.36Issue(3)：100-108,9.DOI:10.3969/j.issn.1671-7856.2026.03.009
酸敏感性离子通道1a在毒品滥用中的研究进展
Research advances in role of acid-sensing ion channel 1a in drug abuse
摘要
Abstract
Acid-sensing ion channel 1a(ASIC1a)is a proton-gated cation channel that is widely expressed in the central nervous system,and is involved in various physiological and pathological processes by regulating calcium and sodium influx,synaptic plasticity,and reward effects.Recent studies have demonstrated that ASIC1a plays a pivotal role in drug abuse,by modulating neuronal excitability,synaptic plasticity,and reward circuitry.ASIC1a has thus emerged as a key molecule in the mechanisms of drug addiction and as a potential therapeutic target.This review systematically summarizes the molecular characteristics of ASIC1a,its neuroregulatory mechanisms,and its regulatory role in drug abuse,aiming to provide novel targets for elucidating the mechanisms of drug addiction and for the development of new strategies for addiction withdrawal therapy.关键词
酸敏感性离子通道1a/毒品成瘾/突触可塑性/钙超载/神经炎症/线粒体功能障碍Key words
acid-sensing ion channel 1a/drug addiction/synaptic plasticity/calcium overload/neuroinflammation/mitochondrial dysfunction分类
医药卫生引用本文复制引用
普珊,许睿珂,李韵兰,李利华,杨根梦,洪仕君..酸敏感性离子通道1a在毒品滥用中的研究进展[J].中国比较医学杂志,2026,36(3):100-108,9.基金项目
国家自然科学基金项目(82202081,82260336,82371898) （82202081,82260336,82371898）
云南省科技厅基础研究项目(202301AT070269,202301AU070216) （202301AT070269,202301AU070216）
云南省科技厅-昆医联合专项(202301AY070001-234,202301AY070001-026) （202301AY070001-234,202301AY070001-026）
昆明医科大学法医毒物学一流学科团队(2024XKTDYS10). （2024XKTDYS10）
