中国比较医学杂志2026，Vol.36Issue(3)：120-130,11.DOI:10.3969/j.issn.1671-7856.2026.03.011
生物材料和组织工程用于治疗创伤性脑损伤的研究进展
Research progress on biomaterials and tissue engineering for treating traumatic brain injury
摘要
Abstract
Traumatic brain injury(TBI)is a leading global cause of mortality and neurological dysfunction.Its pathological process involves both primary and secondary injuries.External forces directly cause vascular rupture and axonal disruption,leading to cerebral hemorrhage and cellular damage;the secondary phase further exacerbates the injury through mechanisms such as neuroinflammation,neuronal degeneration,and mitochondrial dysfunction.Current clinical strategies for TBI management include surgery,pharmacological interventions,hyperbaric oxygen therapy,nutritional support,and hypothermia.While these approaches can alleviate certain symptoms,their efficacy in improving long-term neurological outcomes remains limited.Tissue engineering has provided new strategies for TBI treatment.The application of biomaterials such as hydrogels,electrospun nanofibers,and nanomaterial-based drug delivery systems can create biomimetic microenvironments,overcome the delivery limitations imposed by the blood-brain barrier,and enable coordinated multilevel neural repair.This review aims to summarize recent advances in tissue engineering strategies for TBI treatment,analyze their therapeutic effects and underlying mechanisms,and propose new directions for future research.关键词
创伤性脑损伤/病理机制/组织工程/生物材料Key words
traumatic brain injury/pathological mechanisms/tissue engineering/biomaterials分类
医药卫生引用本文复制引用
邬建飞,刘宇,王彬又,徐茂芽,王薏琳,蔡端芳,谭友果,刘可智..生物材料和组织工程用于治疗创伤性脑损伤的研究进展[J].中国比较医学杂志,2026,36(3):120-130,11.基金项目
国家重点研发计划(2022YFC2009900) （2022YFC2009900）
自贡市医学大数据与智能研究院协同创新项目(2024-YGY-02-04) （2024-YGY-02-04）
自贡市卫生健康委员会科研课题(22yb001,24zd008) （22yb001,24zd008）
自贡市中西医结合研究院协同创新项目(2025ZXY0206,2025ZXY0322) （2025ZXY0206,2025ZXY0322）
自贡市脑科学研究院协同创新类项目(2025NKY0104). （2025NKY0104）
