中国临床药理学与治疗学2026，Vol.31Issue(2)：154-161,8.DOI:10.12092/j.issn.1009-2501.2026.02.002
儿童癫痫综合征药物治疗进展
Advances in pharmacotherapy for pediatric epilepsy syndromes
摘要
Abstract
Epilepsy is one of the most prevalent neurological disorders in children.While pediatric epilepsy is characterized by a diverse range of caus-es and intricate pathological processes,roughly 30%of affected children exhibit resistance to existing pharmacological treatments.It can be classified in-to distinct epilepsy syndromes based on character-istic clinical and electroencephalographic(EEG)fea-tures.Among these,developmental and epileptic encephalopathy(DEE)represents the most severe subtype.Over recent decades,there have been sig-nificant advancements in new anti-seizure medica-tions(ASM),yet the rate of drug-resistant epilepsy cases has not significantly declined.To systematical-ly evaluate therapeutic strategies for pediatric epilepsy syndromes,this review primarily focuses on several relatively common pediatric epilepsy syndromes,including Dravet syndrome,infantile epileptic spasm syndrome(IESS),as well as rare eti-ology-specific DEEs(e.g.KCNQ2-,SCN2A-,SCN8A-,and CDKL5-related DEE),and febrile infection-relat-ed epilepsy syndrome(FIRES).We summarize cur-rent pharmacological management and emerging therapeutic advances in these conditions,aiming to support evidence-based clinical decisions.关键词
儿童/癫痫综合征/发育性癫痫性脑病/抗发作药物Key words
pediatric/epilepsy syndromes/devel-opmental and epileptic encephalopathy(DEE)/anti-seizure medications分类
医药卫生引用本文复制引用
王天爽,王新华,周渊峰..儿童癫痫综合征药物治疗进展[J].中国临床药理学与治疗学,2026,31(2):154-161,8.基金项目
安徽省自然科学基金(2308085MH258) （2308085MH258）
复旦大学医工合作项目(yg2023-15) （yg2023-15）
复旦大学附属儿科医院"医+X"交叉创新团队孵化项目(EKYX202422) （EKYX202422）
复旦大学附属儿科医院"青苗计划"(EKQM202414) （EKQM202414）
