摘要
Abstract
Objective To explore the clinical effects of different doses of remimazolam in painless gastroscopy for the aged obese.Methods 160 aged obese patients who were scheduled to undergo painless gastroscopy from January 2024 to June 2024 were selected.The random number method was used for grouping:group P(propofol,40 cases),group R1(remimazolam 0.20 mg/kg,40 cases),group R2(remimazolam 0.30 mg/kg,40 cases),and group R3(remimazolam 0.40 mg/kg,40 cases).Compare the anesthesia-related conditions and the incidence of adverse reactions among the four groups of patients;The hemodynamic indicators of the four groups of patients before anesthesia induction,3 minutes after endoscopy insertion and at the end of the examination were recorded.Results Compared with group P and group R1,the onset time of sedation in group R2 and group R3 was shorter,and the differences were statistically significant(P<0.05).The recovery time of group R3 was longer than that of group P,group R1 and group R2,and the differences were statistically significant(P<0.05).Compared with group P and group R3,the observation time in the recovery room of group R1 and group R2 was shorter,and the differences were statistically significant(P<0.05).Compared with group P and group R1,group R2 and group R3 had fewer times of remedial sedation,and the differences were statistically significant(P<0.05).There were no statistically significant differences in heart rate(HR),systolic blood pressure(SBP),diastolic blood pressure(DBP),and percutaneous arterial oxygen saturation(SpO2)among the four groups of patients before induction,3 minutes after endoscopy insertion,and at the end of the examination(P>0.05).The incidences of hypotension,respiratory depression,injection pain and bradycardia in group P were significantly higher than those in group R1,group R2 and group R3,and the differences were statistically significant(P<0.05).There were no statistically significant differences in the incidences of hypotension,respiratory depression,injection pain and bradycardia among group R1,group R2 and group R3(P>0.05).Conclusion Remimazolam used for painless gastroscopy in the aged obese patients can reduce the incidence of adverse reactions compared with propofol.When the dose of remifentanil reaches 0.30 mg/kg,the onset time of anesthesia and the observation time in the recovery room can be shortened,and the number of remedial sedations can be reduced.It is worth applying in clinical practice.关键词
瑞马唑仑/无痛胃镜检查/老年/肥胖/丙泊酚/不良反应Key words
remimazolam/painless gastroscopy/the aged/obesity/propofol/adverse reaction分类
医药卫生
