中国中医药信息杂志2026，Vol.33Issue(3)：15-20,6.DOI:10.19879/j.cnki.1005-5304.202506359
基于"阴阳动态平衡"理论探讨自噬双向调控在类风湿关节炎中的作用及中医药干预机制
Exploration on the Role of Autophagy Bidirectional Regulation in Rheumatoid Arthritis and the Intervention Mechanism of TCM Based on the Theory of"Dynamic Balance of Yin and Yang"
摘要
Abstract
The pathological process of rheumatoid arthritis(RA)is closely related to the imbalance of autophagy function.This article,starting from the theory of"dynamic balance of yin and yang"in TCM,explored the role of autophagy in different pathological stages of RA:excessive activation of autophagy,manifested as"positive"pathological function hyperactivity and relatively insufficient"negative"protective function,that is,"excess of yang and deficiency of yin",aggravates inflammation and bone destruction;while low autophagy function,manifested as"negative"clearance function failure and insufficient"positive"repair power,that is,"excess of yin and deficiency of yang",hinders tissue repair.TCM targets key autophagy pathways such as PI3K/AKT/mTOR to bidirectionally regulate autophagy activity,achieving"clearing heat and promoting diuresis"and"tonifying liver and kidney"and other staged treatment strategies.Monomers such as salvianolic acid B and formulas such as Danggui Niantong Decoction and Cheng's Juanbi Decoction significantly inhibit abnormal proliferation of synovial fibroblasts or promote cartilage repair through multi-target effects.By integrating theories of traditional Chinese and Western medicine,it can provide reference ideas for the diagnosis and treatment of RA and theoretical references for the development of new drugs based on autophagy regulation.关键词
阴阳动态平衡/细胞自噬/类风湿关节炎/炎症/中医药Key words
dynamic balance of yin and yang/autophagy/rheumatoid arthritis/inflammation/traditional Chinese medicine分类
医药卫生引用本文复制引用
李永红,李浩林,杨娟娟,景骆羊,宋静静,苏瑾,苏小军,金芳梅,王海东..基于"阴阳动态平衡"理论探讨自噬双向调控在类风湿关节炎中的作用及中医药干预机制[J].中国中医药信息杂志,2026,33(3):15-20,6.基金项目
国家自然科学基金(82260880) （82260880）
王海东甘肃省名中医传承工作室建设项目(2022年) （2022年）
国家中医药管理局高水平中医药重点学科建设项目(2022年) （2022年）
