中国中医药信息杂志2026，Vol.33Issue(3)：51-58,8.DOI:10.19879/j.cnki.1005-5304.202509313
基于隐结构模型和关联规则分析梅尼埃病方药规律
Analysis on Prescription Law of for Ménière's Disease Based on Latent Structure Models and Association Rule Analysis
摘要
Abstract
Objective To explore the prescription law of TCM treatment for Ménière's disease;To provide clinical references.Methods Relevant literature about TCM treatment for Ménière's disease was retrieved from CNKI,Wanfang Data,VIP,SinoMed,PubMed,Web of Science,Cochrane Library,Embase from the establishment of the databases to March 4,2025.Data analysis was conducted on frequency,properties and tastes,meridian tropism and efficacy of Chinese materia medica using Excel 2019.Lantern 5.0 and RStudio were used to perform latent structure modeling,clustering analysis,and association rule analysis on high-frequency Chinese materia medica with a usage frequency of≥3%.Results A total of 397 articles were included,including 441 prescriptions,which involving 222 herbs,with a total frequency of 4 848 times.High-frequency Chinese materia medica included Atractylodis Macrocephalae Rhizoma,Poria,Alismatis Rhizoma and Gastrodiae Rhizoma.The main properties were warm,neutral and cold;the main tastes were sweet,pungent and bitter,mainly entering the spleen,lung and stomach meridians.Key efficacy included tonifying deficiency,promoting diuresis and draining dampness,and calming the liver and extinguishing wind.Latent structure analysis revealed 21 latent variables,42 latent classes,and 7 cluster models,summarizing 25 core formulas.The main syndrome patterns identified were phlegm-dampness obstruction,kidney essence deficiency,liver yang hyperactivity,and qi-blood deficiency.Association rule analysis yielded 47 strong rules;the highest support was Poria → Atractylodis Macrocephalae Rhizoma,and the highest confidence was Atractylodis Macrocephalae Rhizoma+Citri Reticulatae Pericarpium+Glycyrrhizae Radix et Rhizoma → Poria.Conclusion Ménière's disease is characterized by liver-kidney deficiency,qi-blood deficiency,and marrow sea insufficiency in root,with manifestations of wind,fire,phlegm and stasis disturbing the orifices.Treatment should focus on tonifying deficiency and draining excess,harmonizing yin and yang,combined with method of resolving phlegm,dispelling dampness,regulating qi,unblocking stagnation,nourishing the liver and kidney,and calming the liver and subduing yang.关键词
梅尼埃病/隐结构模型/关联规则/方药规律/综合聚类/数据挖掘/LTM-EAST算法/中医药Key words
Ménière's disease/latent structure model/association rules/prescription law/comprehensive clustering/data mining/LTM-EAST algorithm/traditional Chinese medicine分类
医药卫生引用本文复制引用
郝颖煦,冯磊,吴广,赵敏,张道培,孙江燕,朱健,潘知玉,武红莉,荆志伟..基于隐结构模型和关联规则分析梅尼埃病方药规律[J].中国中医药信息杂志,2026,33(3):51-58,8.基金项目
国家自然科学基金(82074584) （82074584）
中国中医科学院中国医史文献研究所科研基本业务费自主选题(ZZ180521) （ZZ180521）
