中国中医药信息杂志2026，Vol.33Issue(3)：59-67,9.DOI:10.19879/j.cnki.1005-5304.202504102
中药复方治疗急性呼吸道感染外寒内热证有效性和安全性的系统评价和Meta分析
Chinese Herbal Compounds for Acute Respiratory Tract Infections with Exterior Cold and Interior Heat Syndrome:A Systematic Review and Meta-analysis
摘要
Abstract
Objective To systematically evaluate the efficacy and safety of Chinese herbal compounds for the treatment of acute respiratory tract infections(ARTI)with exterior cold and interior heat syndrome.Methods Relevant randomized controlled trials(RCTs)were retrieved from CNKI,Wanfang Data,VIP,SinoMed,PubMed and Web of Science.Meta-analysis was performed using the AutoMeta platform.Results A total of 29 RCTs were included,involving 3 445 patients.The Meta-analysis results showed that Chinese herbal compounds could significantly improve the overall clinical efficacy of ARTI with exterior cold and interior heat syndrome(OR=4.66,95%CI[3.04,7.16],P<0.001),shorten the time to fever reduction(MD=-1.07,95%CI[-1.69,-0.46],P<0.001)and time to defervescence(MD=-5.44,95%CI[-8.95,-1.92],P=0.002),and improve clinical symptoms(SMD=-0.64,95%CI[-1.11,-0.17],P=0.007),with reliable clinical safety(OR=0.54,95%CI[0.31,0.93],P=0.02).There was no significant difference between the two groups in shortening the time to complete defervescence(MD=-5.37,95%CI[-12.08,1.34],P=0.12),improving the main symptoms of exterior cold(SMD=-0.67,95%CI[-1.59,0.25],P=0.15)and the main symptoms of interior heat(SMD=-0.64,95%CI[-1.32,0.05],P=0.06).Conclusion Chinese herbal compounds demonstrate good clinical efficacy and safety for the treatment of ARTI with exterior cold and interior heat syndrome.Given the quality and quantity of the included studies,further high-quality RCTs are needed to provide stronger evidence.关键词
中药复方/急性呼吸道感染/外寒内热证/随机对照试验/Meta分析Key words
Chinese herbal compounds/acute respiratory tract infections/exterior cold and interior heat syndrome/randomized controlled trials/Meta-analysis分类
医药卫生引用本文复制引用
刘益诚,钟琳洁,田晨,石嘉恒,房俊钢,齐文升..中药复方治疗急性呼吸道感染外寒内热证有效性和安全性的系统评价和Meta分析[J].中国中医药信息杂志,2026,33(3):59-67,9.基金项目
国家自然科学基金(82474489) （82474489）
中央高水平中医医院临床研究和成果转化能力提升项目(HLCMHPP2023090、HLCMHPP2023091) （HLCMHPP2023090、HLCMHPP2023091）
中国中医科学院科技创新工程(CI2022C004-02、CI2022C005) （CI2022C004-02、CI2022C005）
