中国中医药信息杂志2026，Vol.33Issue(3)：68-74,7.DOI:10.19879/j.cnki.1005-5304.202504720
基于"因虚致病"理论和孟德尔随机化探讨虚弱与肝酶相关性
Exploration on the Correlation between Frailty and Liver Enzymes Based on the Theory of"Illness Caused by Deficiency"and Mendelian Randomization
摘要
Abstract
Objective To investigate the causal relationship between frailty and liver enzyme levels based on the theory of"illness caused by deficiency"in TCM and Mendelian randomization.Methods Using data from genome-wide association studies(GWAS)databases,specific single nucleotide polymorphisms(SNPs)related to frailty and liver enzyme levels were identified and used as instrumental variables.Mendelian randomization analysis was conducted using three methods:inverse variance weighted(IVW),MR-Egger regression,and weighted median,to evaluate the correlation between frailty and liver enzyme levels.Sensitivity analysis and pleiotropy tests were performed,including Cochran's Q test,MR-Egger test,MR-PRESSO test,and leave-one-out analysis,in order to ensure the reliability and robustness of the results.Results After analyzing data from the UK Biobank(UKB)database,a significant positive causal relationship was found between frailty and ALT(Beta=0.095,95%CI:0.036-0.153,P=0.001).The significant correlation was identified between frailty and ALP(Beta=0.144,95%CI:0.054-0.235,P=0.002),frailty and GGT(Beta=0.157,95%CI:0.072-0.242,P<0.001),and frailty and AST(Beta=0.092,95%CI:0.023-0.160,P=0.008).Furthermore,results from the GWAS Catalog database also supported the presence of a positive causal relationship between frailty and ALT,ALP,and GGT(P<0.05).Conclusion There is a significant correlation between frailty and liver enzymes,enriching the biological connotation of the theory of"illness caused by deficiency".At the same time,it is suggested that frailty should be considered as a potential risk factor for elevated liver enzyme levels in clinical practice.关键词
中医理论/因虚致病/孟德尔随机化/虚弱/肝酶水平/因果联系Key words
traditional Chinese medicine theory/illness caused by deficiency/Mendelian randomization/frailty/liver enzyme levels/causal relation分类
医药卫生引用本文复制引用
张哲,蔡栋,赵玲玲,翁舒珅,王洋,李灿东..基于"因虚致病"理论和孟德尔随机化探讨虚弱与肝酶相关性[J].中国中医药信息杂志,2026,33(3):68-74,7.基金项目
国家自然科学基金海峡联合基金(U22A20376) （U22A20376）
国家中医药管理局第二届全国名中医传承工作室建设项目(2022年) （2022年）
