中医杂志2026，Vol.67Issue(3)：277-282,313,7.DOI:10.13288/j.11-2166/r.2026.03.009
功能性便秘中医药临床及基础研究现状
Current Status of Clinical and Basic Research on Traditional Chinese Medicine for Functional Constipation
摘要
Abstract
This paper reviews the literature on the treatment of functional constipation(FC)with traditional Chinese medicine(TCM)to summarize the current status of TCM research in this field.Clinical studies mainly focus on TCM syndrome patterns and therapeutic efficacy.Although research on FC-related TCM syndromes remains limited and lacks high-quality evidence-based medical support,existing evidence indicates that various TCM interventions,including oral herbal medicine,external therapies,acupuncture,acupoint application,acupoint embedding,and tuina massage,can improve FC-related clinical symptoms to varying degrees,with notable therapeutic effects.Moreover,integrative therapies combining TCM and western medicine demonstrate synergistic benefits in FC management.Regarding mechanistic research,one major approach involves animal modeling,including models based on different FC subtypes and combined disease-syndrome models,which serve not only to evaluate therapeutic efficacy and phar-macological mechanisms but also as important tools for exploring the pathophysiology of FC and the biological basis of TCM syndromes.Another approach employs systems biology,network pharmacology,metabolomics,metagenomics,and multi-omics methods to elucidate the molecular targets and signaling pathways of TCM compound formulas,single herbs,and their active components.These studies focus on regulation of the enteric nervous system,improvement of gastrointestinal motility,modulation of fluid metabolism,enhancement of intestinal barrier function,reduction of inflammation,and regulation of gut microbiota and their metabolites,thereby clarifying the pharmacodynamic and pharmacological mechanisms underlying FC treatment.Based on an analysis of the current research landscape,this paper proposes future directions for TCM research on FC.关键词
功能性便秘/中医药疗法/临床疗效/作用机制/文献综述Key words
functional constipation/traditional Chinese medicine therapy/clinical efficacy/action mechanisms/literature review引用本文复制引用
柯晓,袁建业,赵培琳,方文怡,刘启鸿,卞立群,任彦,柯敏辉,唐旭东..功能性便秘中医药临床及基础研究现状[J].中医杂志,2026,67(3):277-282,313,7.基金项目
中国科学技术学会2024年中医脾胃病学学科发展研究(2024XKFZYJ) （2024XKFZYJ）
国家自然科学基金(82274282,82405095) （82274282,82405095）
2023年中央引导地方科技发展专项(2023L3013) （2023L3013）
