中医杂志2026，Vol.67Issue(3)：283-290,8.DOI:10.13288/j.11-2166/r.2026.03.010
感夜平颤方治疗早中期帕金森病伴快速眼动睡眠行为障碍患者睡眠及血压昼夜节律紊乱的临床研究
Ganye Pingchan Decoction(感夜平颤方)for Patients with Early-Moderate Parkinson's Disease Complicated with Rapid Eye Movement Sleep Behavior Disorder on Sleep and Blood Pressure Circadian Rhythm Disorders:A Randomized Controlled Trial
摘要
Abstract
Objective To investigate the clinical effectiveness of Ganye Pingchan Decoction(感夜平颤方)for patients with early-moderate Parkinson's disease(PD)complicated with rapid eye movement sleep behavior disorder(RBD)on sleep and blood pressure circadian rhythm disorders.Methods A total of 80 patients with early-moderate PD patients with RBD were randomly assigned to either a treatment group or a control group,with 40 patients in each group.The control group received conventional western medicine plus placebo of Ganye Pingchan Decoction,while the treatment group received conventional western medicine combined with Ganye Pingchan Decoction.The course of treatment for both groups was 12 weeks.Changes in the Unified Parkinson's Disease Rating Scale(UPDRS),Hong Kong Rapid Eye Movement Sleep Behavior Disorder Questionnaire(RBDQ-HK),Parkinson's Disease Sleep Scale(PDSS),polysomnography(PSG),salivary melatonin(SM)secretion rhythms,and 24-hour ambulatory blood pressure before and after treatment were measured in both groups.Results Compared with the baseline data within group,the scores of RBDQ-HK and UPDRS decreased in both groups after treatment;the PDSSscore increased in the treatment group but decreased in the control group;in the treatment group,sleep efficiency was improved,and the number and index of microarousals reduced;the proportion of N3 sleep stage increased,while rapid eye movement(REM)activity,REM intensity and REM density decreased in both groups;the median SM secretion level increased in both groups,and the amplitude of SM secretion elevated in the treatment group;in the treatment group,the noctur-nal systolic blood pressure decline rate(n-SBP)increased,and the proportion of patients with non-dipper blood pres-sure rhythm raised(P＜0.05).After treatment,the scores of UPDRS and RBDQ-HK,as well as the number and index of microarousals in the treatment group were significantly lower than those in the control group;the daytime mean systolic blood pressure(d-SBP)and Δ n-SBP in the treatment group were higher than those in the control group(P＜0.05).Conclusion Ganye Pingchan Decoction can effectively regulate sleep and blood pressure circadian rhythms in patients with early-moderate PD complicated with RBD.It can improve sleep efficiency,reduce sleep frag-mentation,regulate the circadian rhythm of SM secretion,increase the nocturnal systolic blood pressure decline rate,with good safety.关键词
帕金森病/快速眼动睡眠行为障碍/睡眠节律/血压节律/感夜平颤方Key words
Parkinson's disease/rapid eye movement sleep behavior disorder/sleep rhythm/blood pressure rhythm/Ganye Pingchan Decoction(感夜平颤方)引用本文复制引用
吴攸,叶青,袁灿兴,许黎敏,杨柏灿,杨熠文..感夜平颤方治疗早中期帕金森病伴快速眼动睡眠行为障碍患者睡眠及血压昼夜节律紊乱的临床研究[J].中医杂志,2026,67(3):283-290,8.基金项目
上海市卫生健康委员会科研项目(20224Y0167) （20224Y0167）
国家自然科学基金(82204642) （82204642）
