波谱学杂志2026，Vol.43Issue(1)：61-70,10.DOI:10.11938/cjmr20253175
抗逆转录病毒治疗相关的HIV感染者脑功能动态改变
Antiretroviral Therapy-related Alteration of Brain Functional Dynamics in People with HIV
摘要
Abstract
To investigate the dynamic properties of resting-state functional connectivity associated with antiretroviral therapy(ART),functional magnetic resonance imaging data from 45 treated people with HIV(PWH),56 untreated PWH,and 68 healthy controls were collected.Group independent component analysis and sliding window analysis were conducted to obtain window-functional connectivity matrices,and their dynamic properties were quantified.The results showed that the baseline state and the weakly activated state reflect HIV-related abnormal dynamics and ART-related recovery.The weakly activated state reflected the recovery of cerebellum-related connections and putamen-related functional compensation.The baseline state reflected the recovery of extensive connections except for the visual network.Visual-related connections reflected ART-related adverse reactions in both states.These findings suggest that the cerebellum and putamen may be sensitive biomarkers for ART-related recovery,and the visual network can serve as a target for adjuvant therapy.关键词
人类免疫缺陷病毒/抗逆转录病毒治疗/功能磁共振成像/动态功能连接Key words
HIV/antiretroviral therapy(ART)/functional magnetic resonance imaging(fMRI)/dynamic functional connectivity(dFC)分类
数理科学引用本文复制引用
王奕雯,吴光耀,文之,林富春..抗逆转录病毒治疗相关的HIV感染者脑功能动态改变[J].波谱学杂志,2026,43(1):61-70,10.基金项目
国家自然科学基金资助项目(82472060) （82472060）
中国科学院前沿科学重大突破项目(QYZDB-SSW-SLH046). （QYZDB-SSW-SLH046）
