材料工程2026，Vol.54Issue(3)：39-48,10.DOI:10.11868/j.issn.1001-4381.2025.000292
黄芩苷抗菌水凝胶的制备、表征及药理活性分析
Preparation,characterization and pharmacological activity analysis of baicalin antimicrobial hydrogel
摘要
Abstract
In addressing the inadequate water solubility and bioavailability of baicalin,this study develops a drug carrier that exhibits both antimicrobial and self-healing hydrogel by integrating konjac glucomannan(KGM)-based hydrogel with cyclodextrin encapsulation technology.The successful preparation of baicalin/hydroxypropyl-β-cyclodextrin inclusion complexes is achieved through the utilisation of a saturated solution stirring-freeze-drying method.Subsequent FTIR and XRD analysis demonstrates the effective inclusion of baicalin within the cyclodextrin cavity.The inclusion complexes are loaded into KGM/sodium tetraborate dynamically crosslinked hydrogels,and the resulting hydrogels exhibit excellent swelling properties with a swelling rate of 630.23%.Mechanical tests demonstrate that the hydrogel has significant self-healing capability,with a tensile strength retention rate of 97.80%after healing.In vitro release experiments demonstrate that the system conforms to First-order release model,the cumulative release rate of baicalin reaches 84.33%at 48 h.Antimicrobial experiments confirm that its inhibition rate against Staphylococcus aureus,Escherichia coli and Candida albicans reaches 99.12%,98.07%and 98.82%,respectively,and the DPPH radical scavenging rate is as high as 93.54%.This study proposes a viable methodology for the development of innovative antimicrobial materials and drug carriers,addressing the challenges of low solubility and poor stability associated with baicalin.关键词
黄芩苷/环糊精包合物/自修复水凝胶/抗菌材料/药物释放Key words
baicalin/cyclodextrin inclusion complex/self-healing hydrogel/antimicrobial material/drug release分类
通用工业技术引用本文复制引用
侯伟钊,郭文娟,代昭,罗兴然,张青松..黄芩苷抗菌水凝胶的制备、表征及药理活性分析[J].材料工程,2026,54(3):39-48,10.基金项目
国家自然科学基金项目(32472022) （32472022）
