动物医学进展2026，Vol.47Issue(3)：121-126,6.
CRISPR/Cas9基因编辑动物模型在转化医学研究中的应用
Application of CRISPR/Cas9 Gene Editing Animal Models in Translational Medicine Research
摘要
Abstract
Animal models are important tools for translating therapies from the laboratory to clinical appli-cations.With the continuous development of gene editing technology,construction of gene editing animal models based on clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9(CRISPR/Cas9)offers new possibilities for studying pathogenesis,developing new therapeutic approaches,and evaluating drug efficacy.This paper briefly describes technology and principles of CRISPR/Cas9,sum-marises the application of gene editing animal models in human and animal translational medicine research,and discusses the challenges and solution strategies during the application of CRISPR/Cas9,in order to promote the application of gene editing technology in the construction of animal models.关键词
成簇规则间隔短回文重复序列/CRISPR相关蛋白9/基因编辑/动物模型/疾病/转化医学Key words
CRISPR/Cas9/Gene editing/Animal models/Disease/Translational medicine分类
生物科学引用本文复制引用
郝海生..CRISPR/Cas9基因编辑动物模型在转化医学研究中的应用[J].动物医学进展,2026,47(3):121-126,6.基金项目
中国农业科学院科技创新工程(ASTIP-IAS06) （ASTIP-IAS06）
