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Maternal hypoxia exposure perturbs imprinted gene methylation in adult sperm and induces intergenerational placental impairments in male offspring

Lu-Yao Zhang Gong-Xue Jia Hai-Ping Tao Ke-Xiong Liu Yu-Wen Luo Yun-Peng Hou Qi-En Yang

动物学研究2025，Vol.46Issue(6)：1273-1288,16.

动物学研究2025，Vol.46Issue(6)：1273-1288,16.DOI:10.24272/j.issn.2095-8137.2025.031

Maternal hypoxia exposure perturbs imprinted gene methylation in adult sperm and induces intergenerational placental impairments in male offspring

Lu-Yao Zhang ¹Gong-Xue Jia ¹Hai-Ping Tao ¹Ke-Xiong Liu ²Yu-Wen Luo ³Yun-Peng Hou ³Qi-En Yang⁴

作者信息

1. Key Laboratory of Adaptation and Evolution of Plateau Biota,Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining,Qinghai 810001,China||University of Chinese Academy of Sciences,Beijing 100049,China
2. Institute of Animal Husbandry and Veterinary Medicine,Beijing Academy of Agriculture and Forestry Sciences,Beijing 100097,China
3. State Key Laboratory of Animal Biotech Breeding,College of Biological Sciences,China Agricultural University,Beijing 100193,China
4. Key Laboratory of Adaptation and Evolution of Plateau Biota,Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining,Qinghai 810001,China||University of Chinese Academy of Sciences,Beijing 100049,China||Qinghai Key Laboratory of Animal Ecological Genomics,Northwest Institute of Plateau Biology,Chinese Academy of Sciences,Xining,Qinghai 810008,China
折叠

摘要

关键词

Maternal hypoxia/Sex ratio/Placenta/DNA methylation/Imprinted genes

Key words

Maternal hypoxia/Sex ratio/Placenta/DNA methylation/Imprinted genes

引用本文复制引用

Lu-Yao Zhang,Gong-Xue Jia,Hai-Ping Tao,Ke-Xiong Liu,Yu-Wen Luo,Yun-Peng Hou,Qi-En Yang..Maternal hypoxia exposure perturbs imprinted gene methylation in adult sperm and induces intergenerational placental impairments in male offspring[J].动物学研究,2025,46(6):1273-1288,16.

基金项目

This work was supported by the National Natural Science Foundation of China(32400711,U22A20447),Natural Science Foundation of Qinghai(2025-ZJ-910Q),and"Kunlun Talents"Project from the Qinghai Provincial Government(to Q.E.Y.) （32400711,U22A20447）

动物学研究

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ISSN：0254-5853

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