摘要
Abstract
Knee osteoarthritis(KOA)is a chronic disease characterized by the degeneration of articular cartilage,and its clinical management faces challenges such as poor cartilage regeneration.Platelet-rich plasma(PRP),rich in various growth factors,exhibits potential in promoting cartilage repair,inhibiting inflammation,and modulating bone metabolism.External therapies of Traditional Chinese Medicine,based on the theory of"liver-kidney deficiency and qi stagnation and blood stasis",employ methods such as herbal patches,fumigation,and acupuncture to dispel wind-cold,promote blood circulation,and remove meridian obstruction.The combination of both approaches can alleviate inflammation through multi-target synergistic effects:PRP promotes chondrocyte proliferation and matrix synthesis while upregulating anti-inflammatory factors;Traditional Chinese Medicine external therapies enhance PRP activity by improving local circulation and regulating qi-blood balance.Clinical studies have shown that combined therapies,such as PRP with warm needle acupuncture,acupotomy,or herbal fumigation,can significantly reduce levels of inflammatory and pain mediators compared with single treatments,with good safety profiles.Current research still has limitations,including small sample sizes,lack of standardization in PRP preparation,and incomplete elucidation of synergistic mechanisms.Future efforts should focus on conducting large-sample clinical studies,standardizing PRP preparation protocols,clarifying the synergistic mechanisms of traditional Chinese and Western medicine,and exploring combination therapies with stem cells or personalized treatment strategies to improve the precision and efficacy of KOA management.关键词
膝骨关节炎/富血小板血浆/中医外治法/针灸/针刀Key words
Knee osteoarthritis/Platelet-rich plasma/External therapies of Traditional Chinese Medicine/Acupuncture therapy/Acupotomy分类
医药卫生
