赣南医科大学学报2026，Vol.46Issue(2)：163-170,8.DOI:10.3969/j.issn.2097-7174.2026.02.010
IRF3通过IFN-Ⅰ依赖与非依赖途径双向调控细菌感染的研究进展
Research progress on bidirectional regulation of bacterial infection by IRF3 through IFN-Ⅰ-dependent and independent pathways
摘要
Abstract
Interferon regulatory factor 3(IRF3)is a key member of the interferon regulatory factors(IRFs)family.It is a crucial transcription factor in regulating host-bacteria interactions,and its activation is essential for type Ⅰ interferon(IFN-Ⅰ)-mediated antibacterial defense.However,the function of IRF3 in bacterial infections is not static:changes in the cellular microenvironment or differences in activated signaling pathways can transform it from a"defender"to a"promoter".This article reviews the mechanism of IRF3 as a multifunctional transcription factor in bacterial infections,with a focus on recent research progress in its involvement in different bacterial infection processes through inducing IFN-Ⅰexpression or IFN-Ⅰ-independent signal transduction pathways,with the aim of providing a theoretical basis for the clinical treatment of bacterial infections.关键词
干扰素调节因子3/细菌感染/干扰素Key words
Interferon regulatory factor 3/Bacterial infections/Interferon分类
医药卫生引用本文复制引用
谢小燕,彭艳婷,陈小明,刘志平..IRF3通过IFN-Ⅰ依赖与非依赖途径双向调控细菌感染的研究进展[J].赣南医科大学学报,2026,46(2):163-170,8.基金项目
国家自然科学基金项目(31960163) （31960163）
江西省林业局油茶研究专项项目(YCYJZX2023312) （YCYJZX2023312）
井冈学者科研启动金项目(QD202205) （QD202205）
江西省自然科学基金项目(20242BAB26091) （20242BAB26091）
