摘要
Abstract
Objective To explore the effectiveness of early and adequate supplementation of amino acid and vitamin complexes in treating extrauterine growth retardation(EUGR)in premature infants.Methods 94 premature infants with EUGR who were born and treated at Handan First Hospital from September 2021 to April 2023 were selected as the research subjects(delayed group).They were divided into the experimental group(high-dose amino acid and vitamin complex)and the control group(low-dose amino acid combined with vitamins)based on different intervention methods.The changes in physical growth indicators and serum laboratory indicators of the two groups of children were observed.58 non-EUGR premature infants born in the same hospital during the same period were selected as the normal group.The clinical data of the children were collected,and the influencing factors of EUGR in premature infants were analyzed using the Logistic regression model.Results Compared with the control group,the weight gain rate and height gain rate of the children in the experimental group increased,and the time to regain birth weight and hospital stay were shortened,with statistically significant differences(t ranged from 2.428 to 4.425,P<0.05).Compared with the control group,the total protein,pre-admission prealbumin,and leptin levels in the experimental group increased,with statistically significant differences(t=5.421,3.550,and 6.323 respectively,P<0.05).Compared with the normal group,the gestational age of the delayed group was smaller,the birth weight was lighter,the prealbumin level was lower,and the rates of asphyxia and mechanical ventilation were higher,with statistically significant differences(χ2/t ranged from 3.436 to 13.462,P<0.05).The results of the multivariate Logistic regression analysis showed that small gestational age,low birth weight,asphyxia,admission prealbumin level lower than normal,and mechanical ventilation were all independent risk factors for EUGR in premature infants(OR ranged from 2.168 to 9.403,P<0.05).Conclusion Early and adequate supplementation of amino acid and vitamin complexes is beneficial to the physical growth of premature infants with EUGR.Small gestational age,low birth weight,asphyxia,admission prealbumin level lower than normal,and mechanical ventilation are all independent risk factors for EUGR in premature infants.关键词
氨基酸/维生素/早产儿/宫外生长发育迟缓/影响因素Key words
amino acid/vitamin/premature infant/extrauterine growth retardation/influencing factor分类
医药卫生
