中国妇幼健康研究2026，Vol.37Issue(3)：94-99,6.DOI:10.3969/j.issn.1673-5293.2026.03.014
血清CXCL10、Ghrelin及SOCS3对小儿支气管肺炎病情诊断的临床意义
Clinical significance of serum CXCL10,Ghrelin,and SOCS3 for diagnosis of severity of bronchopneumonia in children
摘要
Abstract
Objective To explore clinical significance of serum CXC chemokine ligand 10(CXCL10),Ghrelin and suppressor of cytokine signaling 3(SOCS3)for diagnosis of severity of bronchopneumonia in children.Methods A total of 228 children with bronchopneumonia who were treated in The First People's Hospital of Suqian City from January 2022 to January 2024 were selected as bronchopneumonia group.According to severity of the children's disease condition,they were divided into mild bronchopneumonia group(156 cases)and severe bronchopneumonia group(72 cases).Another 70 healthy children who underwent physical examination during the same period were selected as the control group.The clinical data of the patients were collected.Enzyme linked immunosorbent assay(ELISA)was applied to detect serum CXCL10,Ghrelin and SOCS3 levels.Multivariate Logistic regression analysis was applied to analyze influencing factors for exacerbation of bronchopneumonia in children.Receiver operating characteristic(ROC)was applied to analyze diagnostic value of serum CXCL10,Ghrelin and SOCS3 for severe bronchopneumonia in children.Results The serum levels of CXCL10,Ghrelin and SOCS3 of the children in the bronchopneumonia group were higher than those in the control group,and the differences were statistically significant(t=10.652,8.554 and 12.727 respectively,all P<0.05).The levels of white blood cell count(WBC),neutrophil count(NEUT),C-reactive protein(CRP),procalcitonin(PCT),CXCL10,Ghrelin and SOCS3 of the children in the severe bronchopneumonia group were higher than those in the mild bronchopneumonia group,and the differences were statistically significant(t=7.621-27.635,all P<0.05).CRP,PCT,CXCL10,Ghrelin,and SOCS3 were risk factors for exacerbation of bronchopneumonia in children(OR=2.063-2.861,all P<0.05).The areas under the curve(AUCs)of CXCL10,Ghrelin and SOCS3 for diagnosing severe bronchopneumonia in children were 0.798,0.719 and 0.786 respectively,while the AUC of combination of the three indexes for diagnosing severe bronchopneumonia in children was 0.923,which was higher than those of individual diagnosis of the three indexes(Z=3.459,5.179 and 4.126 respectively,all P<0.05).Conclusion The serum levels of CXCL10,Ghrelin and SOCS3 of children with severe bronchopneumonia are relatively high.Serum CXCL10,Ghrelin,and SOCS3 are risk factors for exacerbation of bronchopneumonia in children.The combined detection of the three indexes has high diagnostic value for severe bronchopneumonia.关键词
儿童/支气管肺炎/CXC趋化因子配体10/饥饿素/细胞因子信号抑制因子3/病情Key words
children/bronchopneumonia/CXC chemokine ligand 10/Ghrelin/suppressor of cytokine signaling 3/disease condition分类
医药卫生引用本文复制引用
屈林林,张军,杨苗苗..血清CXCL10、Ghrelin及SOCS3对小儿支气管肺炎病情诊断的临床意义[J].中国妇幼健康研究,2026,37(3):94-99,6.基金项目
江苏省2021年省基础研究计划(自然科学基金)(BK20210002) （自然科学基金）
