中国妇幼健康研究2026，Vol.37Issue(3)：100-106,7.DOI:10.3969/j.issn.1673-5293.2026.03.015
多发性子宫肌瘤剔除术前后彩色多普勒超声参数、lncRNA XIST变化对术后复发评估价值
The value of color doppler flow imaging parameters and lncRNA XIST changes before and after multiple uterine fibroids in evaluating postoperative recurrence
摘要
Abstract
Objective To analyze the evaluation value of color doppler flow imaging(CDFI)parameters and the change of long-chain non-coding RNA X-chromosome inactivation specific transcript(lncRNA XIST)before and after the removal of multiple uterine fibroids for postoperative recurrence.Methods A total of 196 patients who underwent the removal of multiple uterine fibroids at Luzhou People's Hospital from January 2022 to February 2024 were selected as the research subjects.They were divided into the recurrence group and the non-recurrence group based on whether they had recurrence 6 months after the operation.Propensity score matching(PSM)was used to reduce the selection bias between the groups.The end-diastolic velocity(EDV),peak systolic blood flow velocity(PSV),uterine artery resistance index(UtA-RI),and uterine artery pulsatility index(UtA-PI)were measured before and 1 month after the operation using the Voluson E10 color Doppler ultrasound diagnostic instrument.lncRNA XIST was measured before and 1 month after the operation using real-time fluorescence quantitative polymerase chain reaction(qRT-PCR).Logistic regression equation was used to analyze the relationship between CDFI parameters,lncRNA XIST,and postoperative recurrence after the removal of multiple uterine fibroids.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of the model.Results 5 subjects were lost to follow-up 6 months after the operation,and 55 cases(28.79%)recurred.After matching,the lncRNA XIST,EDV,PSV,UtA-PI of the recurrence group before the operation were higher than those of the non-recurrence group,and the UtA-RI was lower than that of the non-recurrence group.The differences were statistically significant(t ranged from 11.733 to 16.918,P<0.05).The ROC curve showed that the area under the curve(AUC)of lncRNA XIST,EDV,PSV,UtA-PI,and UtA-RI for predicting postoperative recurrence after the removal of multiple uterine fibroids before the operation was 0.754,0.766,0.792,0.776,and 0.742,respectively.The combined prediction AUC was 0.918,with a sensitivity of 81.82%and a specificity of 92.73%.The combined prediction AUC was higher than the individual prediction(Z ranged from 2.215 to 3.340,P<0.001).According to the cutoff value,the recurrence risk of patients with high values of lncRNA XIST,EDV,PSV,UtA-RI,and UtA-PI was 1.647,1.875,1.406,0.700,and 1.664 times that of patients with low values,respectively.Conclusion Abnormal lncRNA XIST,EDV,PSV,UtA-PI,and UtA-RI all increase the risk of postoperative recurrence after the removal of multiple uterine fibroids.The combination of these five parameters is helpful to improve the predictive value and guide clinical diagnosis and treatment.关键词
子宫肌瘤/多发性/腹腔镜子宫肌瘤剔除术/复发/彩色多普勒超声/长链非编码RNA X染色体失活特异转录本Key words
uterine fibroid/multiple/laparoscopic myomectomy/recurrence/color doppler flow imaging/long-chain non-coding RNA X-chromosome inactivation specific transcript分类
医药卫生引用本文复制引用
陈果,王荔,胡科丹,张柯..多发性子宫肌瘤剔除术前后彩色多普勒超声参数、lncRNA XIST变化对术后复发评估价值[J].中国妇幼健康研究,2026,37(3):100-106,7.基金项目
2024年泸州市医学会科研项目(2024-YXXM-055) （2024-YXXM-055）
