摘要
Abstract
Objective To observe the clinical efficacy of Buhuo Decoction in patients with chronic heart failure(CHF)of heart-kidney yang deficiency syndrome(HKYDS).Methods A total of 98 patients with CHF of heart-kidney yang deficiency syndrome admitted to Nanyang Central Hospital from December 2022 to April 2025 were selected as the study subjects and divided into a control group and an observation group,with 49 cases in each group,using the envelope method.The control group was treated with conventional western medicine oral-ly,including captopril,spironolactone,metoprolol,and dapagliflozin.The observation group received additional treatment with Buhuo Decoction on this basis.After 3 months of treatment,the two groups were compared regard-ing symptom scores(primary symptoms,secondary symptoms,and total scores),clinical efficacy,levels of in-flammatory markers[soluble CD40 ligand(sCD40L),interleukin-1 β(IL-1β),and interleukin-6(IL-6)],cardiac markers[left ventricular ejection fraction(LVEF)and cardiac index(CI)],and the occur-rence of adverse reactions(palpitations,dizziness,gastrointestinal injury,abnormal liver and kidney function,etc).Results After treatment,the TCM symptom scores in the observation group were lower than those in the control group(P＜0.05);the overall clinical efficacy rate in the observation group was 93.88％(46/49),which was superior to that in the control group[79.59％(39/49)](P＜0.05);the levels of sCD40L,IL-1 β,and IL-6 in the observation group were lower than those in the control group(P＜0.05);the LVEF and CI in the observation group were higher than those in the control group(P＜0.05);the overall incidence of ad-verse reactions in the observation group was 8.16％(4/49),compared to 4.08％(2/49)in the control group,with no statistically significant difference between the groups(P＞0.05).Conclusion Buhuo Decoction as an adjunctive therapy for CHF of heart-kidney yang deficiency syndrome can improve clinical symptoms and cardi-ac function,reduce levels of inflammatory factors,and enhance clinical efficacy,with good safety.关键词
慢性心力衰竭/心肾阳虚证/补火汤/中西医结合疗法Key words
Chronic Heart failure/Heart-kidney yang deficiency syndrome/Buhuo Decoction/Integrated tra-ditional Chinese and Western medicine therapy分类
医药卫生
